Carboxy-mesoporous carbon and its excellent adsorption capability for proteins
Carboxy-mesoporous carbon and its excellent adsorption capability for proteins
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DOI：
10.1039/b613899c
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发表时间：
2007-05-14
影响因子：
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通讯作者：
Balasubramanian, Veerappan Vaithilingam
中科院分区：
文献类型：
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作者：
Vinu, Ajayan;Hossian, Kazi Zakir;Balasubramanian, Veerappan Vaithilingam
在这里，我们首次报道了通过使用过硫酸铵溶液（APS）的简单氧化对六方有序介孔碳的功能化。功能化程度可以通过简单地调节氧化参数如氧化时间、APS浓度和氧化温度来容易地控制。通过XRD、氮气吸附、FT-IR和HR-FESEM测量对功能化材料进行了明确的表征。已经发现，官能化的中孔碳，“羧基中孔碳”，显示出比原始中孔碳高两倍的生物分子吸附能力。羧基介孔碳的较高蛋白质吸附容量可能是由于由于通常垂直于CMK-3碳材料的初级介孔取向的小碳棒的氧化而容易接近介孔内部的所有吸附位点。我们期望这种新的方法可以用于在具有不同结构的介孔碳表面上产生COOH官能团，这些官能团可以进一步容易地被各种官能团如胺、维生素和手性分子修饰。此外，这些功能化的介孔碳材料可以用作固定手性胺络合物和salen络合物、氨基酸和纳米颗粒制备的固体和稳定的载体，并且还可以应用于药物递送、分离和吸附技术、色谱系统的柱填充材料和燃料电池阳极装置。
Here we report for the first time on the functionalization of hexagonally ordered mesoporous carbon through a simple oxidation using ammonium persulfate solution (APS). The degree of functionalization can be easily controlled by the simple adjustment of the oxidation parameters such as oxidation time, APS concentration and oxidation temperature. The functionalized materials have been unambiguously characterized by XRD, nitrogen adsorption, FT-IR and HR-FESEM measurements. It has been found that the functionalized mesoporous carbon, "carboxy mesoporous carbon", shows two times higher adsorption capability for biomolecules than pristine mesoporous carbon. The higher protein adsorption capacity of carboxy mesoporous carbon may be due to the easy access of all the adsorption sites in the interior part of the mesopores because of the oxidation of small carbon rods which are normally oriented perpendicular to the primary mesopores of CMK-3 carbon material. We expect that this novel methodology could be used to create COOH functional groups on the surface of the mesoporous carbons with different structures which can further easily be modified with various functionalities such as amines, vitamins and chiral molecules. Moreover, these functionalized mesoporous carbon materials can be utilized as a solid and stable support for immobilizing chiral amine complexes and salen complexes, amino acids and nanoparticle fabrication and may also be applicable in drug delivery, separation and adsorption technology, column packing materials for chromatographic system and fuel cell anodic devices.