Enhanced or impaired cognitive function in Parkinson's disease as a function of dopaminergic medication and task demands
Enhanced or impaired cognitive function in Parkinson's disease as a function of dopaminergic medication and task demands
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DOI：
10.1093/cercor/11.12.1136
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发表时间：
2001-12-01
期刊：
影响因子：
3.7
通讯作者：
Robbins, TW
中科院分区：
文献类型：
--
作者：
Cools, R;Barker, RA;Robbins, TW
我们研究了多巴胺（DA）系统如何有助于认知性能的学习和注意力的灵活性领域，通过检查帕金森病（PD）患者的DA能药物的影响。药物治疗的障碍，在两个任务之间的切换，被认为是依赖于电路连接背外侧前额叶皮层和后顶叶皮层的背尾状核，这是深刻的DA耗尽PD。相比之下，相同的药物损害概率逆转学习，涉及眶额皮质-腹侧纹状体回路，这是相对幸免于DA损失的PD。因此，DA能药物改善或损害认知能力取决于任务的性质和基础皮质-纹状体回路中DA功能的基础水平。
We investigated how dopamine (DA) systems contribute to cognitive performance in the domain of learning and attentional flexibility by examining effects of withdrawing DA-ergic medication in patients with Parkinson's disease (PD). Medication remediated impairments in switching between two tasks, thought to depend on circuitry connecting the dorsolateral prefrontal cortex and the posterior parietal cortex to the dorsal caudate nucleus, which is profoundly DA-depleted in PD. By contrast, the same medication impaired probabilistic reversal learning that implicates orbitofrontal cortex-ventral striatal circuitry, which is relatively spared of DA loss in PD. Hence, DA-ergic medication improves or impairs cognitive performance depending on the nature of the task and the basal level of DA function in underlying cortico-striatal circuitry.