Beneficial effect of hesperidin on lipopolysaccharide-induced hepatotoxicity
Beneficial effect of hesperidin on lipopolysaccharide-induced hepatotoxicity
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DOI：
10.1016/j.tox.2006.06.018
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发表时间：
2006-09-21
期刊：
影响因子：
4.5
通讯作者：
Chopra, Kanwaljit
中科院分区：
文献类型：
--
作者：
Kaur, Gaganjit;Tirkey, Naveen;Chopra, Kanwaljit
橙皮苷（Hesperidin，HDN）是一种黄酮苷，广泛存在于柑橘类水果中.据报道，HDN具有显著的抗过敏、痔疮、激素紊乱和溃疡的活性。其他报道的活性包括抗炎、镇痛、抗菌、抗真菌、抗病毒、抗氧化和自由基清除剂活性。内毒素的一个潜在的重要作用是增加活性氧中间体如O-2（中心点-）、过氧化物和一氧化氮的产生。本文报道的研究表明，HDN在改善内毒素诱导的大鼠肝脏功能障碍和氧化应激方面具有有益的作用。以1 mg/kg单剂量腹腔注射脂多糖（LPS）诱导大鼠肝毒性。观察到肝酶（ALT、AST、ALP）和总胆红素（p < 0.05）血清水平升高，表明存在明显的肝功能障碍。血清和组织亚硝酸盐水平也有所增加。LPS的挑战进一步增加硫代巴比妥酸反应物质（TBARS）的水平，而谷胱甘肽（GSH）的含量和超氧化物歧化酶（SOD）的活性下降，在大鼠肝匀浆中显示出显着的氧化应激。HDN给药成功地和剂量依赖性地减弱了LPS的这些作用。总之，这些研究结果表明，HDN可能通过防止NO和氧自由基的细胞毒性作用来减轻LPS诱导的肝毒性。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
Hesperidin (HDN) is a flavanone glycoside abundantly found in citrus fruits. HDN has been reported to possess significant activities against allergy, heammorrhoids, hormonal disorders and ulcers. Other reported activities include anti-inflammatory, analgesic, antibacterial, antifungal, antiviral, antioxidant and free radical scavenger activity. A potentially important effect of endotoxin is the increased production of reactive oxygen intermediates as O-2(center dot-), peroxides and nitric oxide. The study reported here show a beneficial effect of HDN in amelioration of endotoxin-induced hepatic dysfunction and oxidative stress in the liver of rats. Hepatotoxicity was induced by administering lipopolysaccharide (LPS), in a single dose of 1 mg/kg intraperitoneally to the rats. A marked hepatic dysfunction evident by rise in serum levels of liver enzymes (ALT, AST, ALP) and total bilirubin (p < 0.05) was observed. Serum and tissue nitrite levels were also increased. LPS challenge further increased thiobarbituric acid reactive substances (TBARS) levels, whereas glutathione (GSH) content and superoxide dismutase (SOD) activity were decreased in the liver homogenates of the rats showing a marked oxidative stress. HDN administration successfully and dose dependently attenuated these effects of LPS. In conclusion, these findings suggest that HDN attenuates LPS-induced hepatotoxicity possibly by preventing cytotoxic effects of NO and oxygen free radicals. (c) 2006 Elsevier Ireland Ltd. All rights reserved.