Increased Incidence of Depression and Chronic Pain in Traumatic Spinal Cord Injury Patients With Pre-Injury Alcohol Use Disorder: Longitudinal Analysis of Insurance Claim Database.
Increased Incidence of Depression and Chronic Pain in Traumatic Spinal Cord Injury Patients With Pre-Injury Alcohol Use Disorder: Longitudinal Analysis of Insurance Claim Database.
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DOI：
10.1089/neur.2023.0096
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发表时间：
2024
影响因子：
2.4
通讯作者：
Hetman, Michal
中科院分区：
文献类型：
--
作者：
Ugiliweneza, Beatrice;Wang, Dengzhi;Rood, Benjamin;Boakye, Maxwell;Castillo, Camilo;Hetman, Michal
关键词：
酒精使用障碍（AUD）会增加创伤性脊髓损伤（SCI）的风险，并与抑郁，焦虑和慢性疼痛有关。鉴于这些神经精神疾病在SCI患者中经常观察到，使用保险索赔数据库分析了损伤前AUD对抑郁，焦虑或慢性疼痛风险的影响。在10，591名创伤性SCI患者中，507名在受伤前12个月内有过AUD相关索赔。这些AUD阳性的SCI患者表现出明显的人口统计学特征，包括男性比例更高、年龄更小、合并症更多、商业保险覆盖率更低以及颈部损伤更多。AUD组还显示出抑郁、焦虑和慢性疼痛的损伤前共病升高。然而，多元回归分析显示，AUD患者在伤后6个月（1.671; 95%置信区间[CI]：1.124，2.483）和伤后1年（1.511; 95% CI：1.071，2.131）时，SCI后抑郁的重新诊断的比值比（OR）增加。SCI后焦虑的OR不受损伤前AUD的影响。最后，SCI后1年，损伤前AUD增加了损伤后慢性疼痛重新诊断的OR（1.545; 95% CI：1.223，1.951）。因此，损伤前AUD可能是创伤性SCI后抑郁和慢性疼痛发展的危险因素。
Alcohol use disorder (AUD) increases risk of traumatic spinal cord injury (SCI) and is associated with depression, anxiety, and chronic pain. Given that these neuropsychiatric morbidities are frequently observed in SCI patients, the effects of pre-injury AUD on risk of depression, anxiety, or chronic pain were analyzed using an insurance claim database. Of 10,591 traumatic SCI patients, 507 had AUD-associated claims in a 12-month period before injury. Those AUD-positive SCI patients showed distinct demographic characteristics, including greater representation of men, younger age, more comorbidities, lower coverage by commercial insurance, and more cervical-level injuries. The AUD group also showed elevated pre-injury comorbidity of depression, anxiety, and chronic pain. However, multi-regression analysis revealed an increased odds ratio (OR) of de novo diagnosis of post-SCI depression in AUD patients 6 months (1.671; 95% confidence interval [CI]: 1.124, 2.483) and 1 year post-injury (1.511; 95% CI: 1.071, 2.131). The OR of de novo post-SCI anxiety was unaffected by pre-injury AUD. Finally, 1 year after SCI, pre-injury AUD increased the OR of de novo diagnosis of post-injury chronic pain (1.545; 95% CI: 1.223, 1.951). Thus, pre-injury AUD may be a risk factor for development of depression and chronic pain after traumatic SCI.
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影响因子：
2.2
作者：
Peterson MD;Meade MA;Lin P;Kamdar N;Rodriguez G;Krause JS;Mahmoudi E
通讯作者：
Mahmoudi E
影响因子：
4.2
作者：
Bombardier, Charles H.;Hoekstra, Trynke;Fann, Jesse R.
通讯作者：
Fann, Jesse R.
DOI：
10.1097/00005373-199609000-00002
发表时间：
1996-09-01
影响因子：
--
作者：
Osler, T;Rutledge, R;Bedrick, E
通讯作者：
Bedrick, E
DOI：
10.1016/j.apmr.2003.12.041
发表时间：
2004-09-01
影响因子：
4.3
作者：
Dikmen, SS;Bombardier, CH;Temkin, NR
通讯作者：
Temkin, NR
影响因子：
3
作者：
Elixhauser, A;Steiner, C;Coffey, RN
通讯作者：
Coffey, RN