Three-dimensional photoacoustic imaging of blood vessels in tissue
Three-dimensional photoacoustic imaging of blood vessels in tissue
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DOI：
10.1364/ol.23.000648
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发表时间：
1998-04-15
期刊：
影响因子：
3.6
通讯作者：
Dekker, A
中科院分区：
文献类型：
--
作者：
Hoelen, CGA;de Mul, FFM;Dekker, A
我们应用光声作为用于检测血液浓度的组织断层扫描技术，例如，肿瘤周围的血管生成。我们使用532 nm的光对高度散射样本中的血管进行成像，深度接近1 cm。样品为真实的组织（鸡胸肉）或10%稀释的Intradenoid-10%。血液流过尼龙毛细血管。聚偏二氟乙烯（PVdF）压电探测器使用的表面扫描模式。我们证明了该技术的灵敏度，通过光声检测单个红细胞在玻璃板上。横向分辨率受探测器直径（200 μ m）的限制。深度分辨率接近10 μ m。(C)1998年美国光学学会。
We applied photoacoustics as a tissue tomography technique for the detection of blood concentrations, e.g., angiogenesis around tumors. We imaged blood vessels in highly scattering samples, using 532-nm light, to depths of similar to 1 cm. The samples were real tissue (chicken breast) or 10% dilutions of Intralipid-10%. The blood flowed through nylon capillaries. Polyvinylidene difluoride (PVdF) piezoelectric detectors were used in a surface-scanning mode. We demonstrate the sensitivity of the technique by photoacoustic detection of single red blood cells upon a glass plate. Lateral resolution is limited by the detector diameter (200 mu m). The depth resolution is similar to 10 mu m. (C) 1998 Optical Society of America.