Bang-bang model for regulation of local blood flow.
Bang-bang model for regulation of local blood flow.
复制标题
DOI：
10.1111/micc.12051
复制
发表时间：
2013-08
期刊：
影响因子：
--
通讯作者：
Pittman RN
中科院分区：
文献类型：
--
作者：
Golub AS;Pittman RN
肌肉组织血流代谢调节的经典模型意味着静息肌肉小动脉的基础张力的维持及其通过肌细胞诱发血管舒张代谢物的产生来响应运动和/或组织缺氧而扩张。一个世纪以来，人们一直在努力寻找解释活性和反应性充血的特定代谢物，但并未成功。此外，代谢理论与生理自由基（例如一氧化氮，NO和超氧阴离子，O2−）在微血管张力调节中的作用的新知识不相容。我们提出了一种调节模型，其中肌肉收缩和主动充血被认为是生理正常状态。我们采用“bang-bang”或“开/关”监管模式，利用阈值和滞后作用；控制水箱中水位的浮阀是此类调节的常见示例。当氧气和葡萄糖的供应超过需求时，主动的爆炸式调节就会生效，导致膜 NADPH 氧化酶激活，将 O2− 释放到间隙空间，随后中和间隙 NO。当局部血流超过阈值时，小动脉的打开/关闭是由具有开关式控制器特性的本地单元电路实现的，由其阈值、滞后和死区决定。该模型对平衡组织需求与充足的营养和氧气供应的机制提供了清晰明确的解释。
The classical model of metabolic regulation of blood flow in muscle tissue implies the maintenance of basal tone in arterioles of resting muscle and their dilation in response to exercise and/or tissue hypoxia via the evoked production of vasodilator metabolites by myocytes. A century-long effort to identify specific metabolites responsible for explaining active and reactive hyperemia has not been successful. Furthermore, the metabolic theory is not compatible with new knowledge on the role of physiological radicals (e.g., nitric oxide, NO, and superoxide anion, O2−) in the regulation of microvascular tone. We propose a model of regulation in which muscle contraction and active hyperemia are considered the physiologically normal state. We employ the “bang-bang” or “on/off” regulatory model which makes use of a threshold and hysteresis; a float valve to control the water level in a tank is a common example of this type of regulation. Active bang-bang regulation comes into effect when the supply of oxygen and glucose exceeds the demand, leading to activation of membrane NADPH oxidase, release of O2− into the interstitial space and subsequent neutralization of the interstitial NO. Switching arterioles on/off when local blood flow crosses the threshold is realized by a local cell circuit with the properties of a bang-bang controller, determined by its threshold, hysteresis and dead-band. This model provides a clear and unambiguous interpretation of the mechanism to balance tissue demand with a sufficient supply of nutrients and oxygen.
登录
查看更多内容
影响因子：
--
作者：
Afanas'ev I
通讯作者：
Afanas'ev I
DOI：
10.1016/j.niox.2010.08.003
发表时间：
2010-12-15
期刊：
Nitric oxide : biology and chemistry
影响因子：
--
作者：
Andrews AM;Jaron D;Buerk DG;Kirby PL;Barbee KA
通讯作者：
Barbee KA
DOI：
10.1073/pnas.74.8.3203
发表时间：
1977-01-01
影响因子：
11.1
作者：
ARNOLD, WP;MITTAL, CK;MURAD, F
通讯作者：
MURAD, F
影响因子：
20.1
作者：
ARCHER, SL;HUANG, J;WEIR, EK
通讯作者：
WEIR, EK
DOI：
10.1152/ajpheart.2000.279.6.h2872
发表时间：
2000-12-01
影响因子：
4.8
作者：
Barron, JT;Gu, LP;Parrillo, JE
通讯作者：
Parrillo, JE