Effects of Exercise Intensity on Postexercise Endothelial Function and Oxidative Stress.
Effects of Exercise Intensity on Postexercise Endothelial Function and Oxidative Stress.
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DOI：
10.1155/2015/723679
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发表时间：
2015
影响因子：
--
通讯作者：
Davison GW
中科院分区：
文献类型：
--
作者：
McClean C;Harris RA;Brown M;Brown JC;Davison GW
目的。在不同强度的运动后90分钟和3小时，立即测量内皮功能和氧化应激。方法。16名明显健康的男性完成了三组30分钟的跑步机运动，速度为55%（轻度）；75%（中等）20分钟；或者5分钟，100%（最大），随机顺序。采用静脉血测定内皮素-1 （ET-1）、脂质氢过氧化物（LOOHs）和脂溶性抗氧化剂，评估肱动脉血流介导扩张（FMD）。结果。中度运动后LOOH立即升高（P < 0.05）。轻度组运动后即刻、运动后3 h ET-1均高于剧烈组（P < 0.05）。最大运动后ΔFMD/ShearAUC较基线出现短暂性下降，但在运动后3小时恢复正常（P < 0.05）。运动后立即剪切率高于轻度运动（P < 0.05）。在任何运动试验后，基线直径、峰值直径、绝对直径变化或FMD均未观察到变化（P < 0.05）。结论。不同强度的急性运动对氧化应激、剪切速率和ET-1产生不同的影响，这些影响似乎不会介导FMD测量的内皮功能的变化。
Purpose. To measure endothelial function and oxidative stress immediately, 90 minutes, and three hours after exercise of varying intensities. Methods. Sixteen apparently healthy men completed three exercise bouts of treadmill running for 30 minutes at 55% (mild); 20 minutes at 75% (moderate); or 5 minutes at 100% (maximal) in random order. Brachial artery flow-mediated dilation (FMD) was assessed with venous blood samples drawn for measurement of endothelin-1 (ET-1), lipid hydroperoxides (LOOHs), and lipid soluble antioxidants. Results. LOOH increased immediately following moderate exercise (P < 0.05). ET-1 was higher immediately after exercise and 3 hours after exercise in the mild trial compared to maximal one (P < 0.05). Transient decreases were detected for ΔFMD/ShearAUC from baseline following maximal exercise, but it normalised at 3 hours after exercise (P < 0.05). Shear rate was higher immediately after exercise in the maximal trial compared to mild exercise (P < 0.05). No changes in baseline diameter, peak diameter, absolute change in diameter, or FMD were observed following any of the exercise trials (P > 0.05). Conclusions. Acute exercise at different intensities elicits varied effects on oxidative stress, shear rate, and ET-1 that do not appear to mediate changes in endothelial function measured by FMD.