HEDOS-a computational tool to assess radiation dose to circulating blood cells during external beam radiotherapy based on whole-body blood flow simulations.
HEDOS-a computational tool to assess radiation dose to circulating blood cells during external beam radiotherapy based on whole-body blood flow simulations.
复制标题
DOI：
10.1088/1361-6560/ac16ea
复制
发表时间：
2021-08-03
影响因子：
3.5
通讯作者：
Grassberger C
中科院分区：
文献类型：
--
作者：
Shin J;Xing S;McCullum L;Hammi A;Pursley J;Correa CA;Withrow J;Domal S;Bolch W;Paganetti H;Grassberger C
我们已经开发了一个时间依赖性计算框架，血液剂量（HEDOS），以估计剂量循环血细胞从放射治疗治疗领域的任何治疗部位。在HEDOS中实现了两个独立的动态模型：一个描述器官中血液颗粒（BP）的时空分布，第二个描述随时间变化的辐射场传递。基于ICRP Publication 89中的血容量和血流量，模拟了全身血液流动网络，使用离散时间马尔可夫过程产生全身器官中BP的时空分布。应用恒定或随时间变化的跃迁概率，并研究它们对跃迁时间的影响。使用来自肝癌和脑癌患者的成像数据和剂量分布研究了治疗时间和解剖部位的影响。模拟结果显示，由于两个器官的血流特性不同，即使在相似的射野大小下，脑照射与肝照射对循环血液的剂量水平也不同。对于脑癌治疗，在单次辐射分次之后接收任何剂量（V>0Gy）的血液体积从1秒递送时间的1.2%增加到120秒递送时间的20.9%，并且对于肝癌治疗，从10%（1秒）增加到48.7%（120秒）。低剂量浴对循环血液的其他测量，如对小体积血液的剂量（D2%），随着输送时间的延长而降低。此外，我们证明了血液剂量体积直方图是高度敏感的治疗时间的变化，表明血流和辐射场的动态建模是必要的，以评估剂量的循环血细胞辐射诱导的淋巴细胞减少症的评估。HEDOS是公开可用的，允许基于器官DVH估计循环血细胞的患者特定剂量，从而能够研究不同治疗计划、剂量率和分次方案的影响。
We have developed a time-dependent computational framework, hematological dose (HEDOS), to estimate dose to circulating blood cells from radiation therapy treatment fields for any treatment site. Two independent dynamic models were implemented in HEDOS: one describing the spatiotemporal distribution of blood particles (BPs) in organs and the second describing the time-dependent radiation field delivery. A whole-body blood flow network based on blood volumes and flow rates from ICRP Publication 89 was simulated to produce the spatiotemporal distribution of BPs in organs across the entire body using adiscrete-time Markov process. Constant or time-varying transition probabilities were applied and their impact on transition time was investigated. The impact of treatment time and anatomical site were investigated using imaging data and dose distributions from a liver cancer and a brain cancer patient. The simulations revealed different dose levels to the circulating blood for brain irradiation compared to liver irradiation even for similar field sizes due to the different blood flow properties of the two organs. The volume of blood receiving any dose (V>0Gy) after a single radiation fraction increases from 1.2% for a 1 s delivery time to 20.9% for 120 s delivery time for the brain cancer treatment, and from 10% (1 s) to 48.7% (120 s) for a liver cancer treatment. Other measures of the low-dose bath to the circulating blood such as the dose to small volumes of blood (D2%) decreases with longer delivery time. Furthermore, we demonstrate that the blood dose-volume histogram is highly sensitive to changes in the treatment time, indicating that dynamic modeling of blood flow and radiation fields is necessary to evaluate dose to circulating blood cells for the assessment of radiation-induced lymphopenia. HEDOS is publicly available and allows for the estimation of patient-specific dose to circulating blood cells based on organ DVHs, thus enabling the study of the impact of different treatment plans, dose rates, and fractionation schemes.
登录
查看更多内容
影响因子：
3.5
作者：
Hammi A;Paganetti H;Grassberger C
通讯作者：
Grassberger C
影响因子：
5.7
作者：
Lee, Byung Min;Byun, Hwa Kyung;Seong, Jinsil
通讯作者：
Seong, Jinsil
影响因子：
2.4
作者：
Debbaut, Charlotte;Segers, Patrick;Monbaliu, Diethard
通讯作者：
Monbaliu, Diethard
影响因子：
1.5
作者：
Liao, Jason J. Z.;Liu, Guanghan Frank
通讯作者：
Liu, Guanghan Frank
影响因子：
3.9
作者：
Mendez JS;Govindan A;Leong J;Gao F;Huang J;Campian JL
通讯作者：
Campian JL