Continuous flow-driven inversion for arterial spin labeling using pulsed radio frequency and gradient fields.
Continuous flow-driven inversion for arterial spin labeling using pulsed radio frequency and gradient fields.
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DOI：
10.1002/mrm.21790
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发表时间：
2008-12
影响因子：
3.3
通讯作者：
Alsop, David C.
中科院分区：
文献类型：
--
作者：
Dai, Weiying;Garcia, Dairon;de Bazelaire, Cedric;Alsop, David C.
通过流动驱动绝热反转进行连续标记对于动脉自旋标记（ASL）灌注研究是有利的，但是实施细节（包括低效、磁化转移和对临床扫描仪上的连续模式操作的有限支持）限制了该方法的益处。在这里，一种新的方法，采用快速重复的梯度和RF脉冲，以实现连续标记，高效率的特点是连续标记。的理论基础，数值模拟，并在体内实现这种脉冲连续ASL（PCASL）的描述。相对于具有可比标记参数的连续标记，96%的体内PCASL标记效率远远超过PCASL RF脉冲的33%占空比。很容易实现在3特斯拉下使用体线圈传输的成像。该技术应有助于实现临床成像仪中连续标记的益处。
Continuous labeling by flow driven adiabatic inversion is advantageous for arterial spin labeling (ASL) perfusion studies, but details of the implementation, including inefficiency, magnetization transfer, and limited support for continuous-mode operation on clinical scanners has restricted the benefits of this approach. Here a new approach to continuous labeling that employs rapidly repeated gradient and RF pulses to achieve continuous labeling with high efficiency is characterized. The theoretical underpinnings, numerical simulations, and in-vivo implementation of this pulsed continuous ASL (PCASL) are described. In-vivo PCASL labeling efficiency of 96% relative to continuous labeling with comparable labeling parameters far exceeded the 33% duty cycle of the PCASL RF pulses. Imaging at 3 Tesla with body coil transmission was readily achieved. This technique should help to realize the benefits of continuous labeling in clinical imagers.
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影响因子：
3.3
作者：
Alsop, DC
通讯作者：
Alsop, DC
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1.5
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