Nicotine self-administration in animals as a dependence model.
Nicotine self-administration in animals as a dependence model.
复制标题
DOI：
10.1080/14622299050011121
复制
发表时间：
1999-03-01
期刊：
影响因子：
--
通讯作者：
Corrigall, W A
中科院分区：
文献类型：
--
作者：
Corrigall, W A
现在存在各种尼古丁依赖的动物模型。要研究尼古丁的积极强化作用，可以选择动物种类、品系和可操作的范例。这份手稿描述了一种特殊范式的使用，这是一种由实验室动物进行工作以获得尼古丁静脉输注的模型。这个模型对于研究大脑中负责维持吸毒行为的机制特别有用。讨论了两个正在进行的依赖机制研究的例子：胆碱能投射到中脑多巴胺细胞的作用，以及阿片受体在这些相同的多巴胺细胞附近的影响。
Various animal models of nicotine dependence now exist. To study the positive reinforcing effects of nicotine, there are choices of animal species, strains, and operant paradigms to use. This manuscript describes the use of one particular paradigm, a model in which work is done by laboratory animals to obtain intravenous infusions of nicotine. This model is particularly useful for examining the mechanisms in the brain that are responsible for the maintenance of drug-taking behavior. Two examples of ongoing studies of the mechanisms of dependence are discussed: the role of cholinergic projections to midbrain dopamine cells, and the influence of opioid receptors in the vicinity of these same dopamine cells.