Discovery and optimization of a series of quinazolinone-derived antagonists of CXCR3
Discovery and optimization of a series of quinazolinone-derived antagonists of CXCR3
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DOI：
10.1016/j.bmcl.2007.03.106
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发表时间：
2007-06-15
影响因子：
2.7
通讯作者：
Medina, Julio
中科院分区：
文献类型：
--
作者：
Johnson, Michael;Li, An-Rong;Medina, Julio
合成了一系列喹唑啉酮类CXCR3受体抑制剂，并评价了它们与受体的亲和力。化合物在I-125-IP10置换实验和体外细胞迁移实验中使用人外周血单核细胞对I-P10、ITAC和MIG进行评估。(C)2007爱思唯尔有限公司。保留所有权利。
A series of quinazolinone-derived inhibitors of the CXCR3 receptor have been synthesized and their affinity for the receptor evaluated. Compounds were evaluated in a I-125-IP10 displacement assay and in in vitro cell migration assays to I P 10, ITAC, and MIG using human peripheral blood mononuclear cells. (c) 2007 Elsevier Ltd. All rights reserved.