Hippocampal mean diffusivity and memory in healthy elderly individuals A cross-sectional study
Hippocampal mean diffusivity and memory in healthy elderly individuals A cross-sectional study
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DOI：
10.1212/wnl.0b013e3181cb3e39
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发表时间：
2010-01-19
期刊：
影响因子：
9.9
通讯作者：
Spalletta, Gianfranco
中科院分区：
文献类型：
--
作者：
Carlesimo, Giovanni A.;Cherubini, Andrea;Spalletta, Gianfranco
背景：年龄相关性记忆减退与海马区解剖改变之间的关系一直存在争议。目的：在一组健康个体中，研究年龄相关性记忆减退与MRI海马区解剖改变的关系。方法：这项横断面研究从2005年至2008年从大学、社区娱乐中心、医院工作人员和患者亲属中招募了76名年龄在20~80岁之间的健康人。这些人接受了3-T磁共振成像方案，进行了全脑T1加权和扩散加权扫描，并进行了神经心理学评估。对于每个受试者，我们计算了整个大脑(灰质+白质)和海马体的体积。分割的海马区定义二值掩模，计算平均弥散率(MD)和分数各向异性(FA)的平均值。神经心理学评估包括言语记忆(15分钟延迟回忆15个单词)和视觉空间记忆(延迟20分钟Rey复杂图形再现)测试。结果：50岁以上老年人在言语记忆和视觉空间记忆测试中的表现与海马区MD有关，但不能预测海马区FA、海马体积或总脑容量。结论：健康老年人海马区平均扩散率高预示记忆能力下降，这反映在陈述性言语记忆和视觉空间记忆测试上。神经病学(R)2010；74：194-200
Background: The relationship between age-related memory decline and hippocampal anatomic changes is a matter of debate.Objectives: To investigate the relationship between age-related memory decline and MRI hippocampal anatomic changes in a cohort of healthy individuals.Methods: In this cross-sectional study, 76 healthy individuals ( 44 male and 32 female), ranging in age from 20 to 80 years, were recruited from universities, community recreational centers, hospital personnel, and patients' relatives from 2005 to 2008. These individuals were submitted to a 3-T MRI protocol with a whole-brain T1-weighted and diffusion-weighted scanning and a neuropsychological assessment. For each subject, we calculated the volumes of the total brain ( gray + white matter) and hippocampi. The segmented hippocampi defined the binary masks where mean values of mean diffusivity ( MD) and fractional anisotropy ( FA) were calculated. Neuropsychological evaluation included tests of verbal memory ( 15 minutes delayed recall of a 15-word list) and visuospatial memory ( 20 minutes delayed reproduction of Rey complex figure).Results: Hippocampal MD, but not hippocampal FA, hippocampal volume, or total brain volume, predicted performance of individuals beyond their 50s on tests of verbal and visuospatial memory.Conclusions: High mean diffusivity values in the hippocampal formation of healthy elderly individuals predict memory decline, as reflected by performance on tests of declarative verbal and visual-spatial memory. Neurology (R) 2010; 74: 194-200