Polyclonal B lymphocyte activation induced by mouse hepatitis virus A59 infection
Polyclonal B lymphocyte activation induced by mouse hepatitis virus A59 infection
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DOI：
10.1099/0022-1317-77-5-1005
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发表时间：
1996-05-01
影响因子：
3.8
通讯作者：
Coutelier, JP
中科院分区：
文献类型：
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作者：
Lardans, V;Godfraind, C;Coutelier, JP
小鼠肝炎病毒 (MHV) 对免疫反应有不同的影响，具体取决于病毒株和小鼠遗传背景。在这里，我们研究了 MHV-A59 感染对 129/Sv 和 CBA 小鼠 B 细胞反应的影响。我们的结果表明，在这些菌株中，MHV-A59 诱导脾细胞活化，导致脾脏增大，但结构没有改变。感染触发 B 淋巴细胞产生大量免疫球蛋白 G2a，大部分没有病毒特异性。这种多克隆免疫球蛋白的产生依赖于功能性 T 辅助细胞的存在。 MHV-A59 感染诱导的这种多克隆 B 淋巴细胞活化可能具有病理学意义，例如伴随的自身免疫反应的增强。
Mouse hepatitis viruses (MHV) diversely affect immune responses, depending on the viral strain and the mouse genetic background. Here, we studied the effect of MHV-A59 infection on B cell responses of 129/Sv and CBA mice. Our results indicate that in these strains, MHV-A59 induces spleen cell activation that leads to enlargement of the spleen without structural alteration. Infection triggers production by B lymphocytes of large amounts of immunoglobulin G2a, mostly without viral specificity. This polyclonal immunoglobulin production is dependent on the presence of functional T helper cells. This polyclonal B lymphocyte activation induced by MHV-A59 infection can have pathological implications, such as the enhancement of concomitant autoimmune reactions.