EPIDEMIOLOGICAL CHARACTERISTICS OF PLATELET AGGREGABILITY
EPIDEMIOLOGICAL CHARACTERISTICS OF PLATELET AGGREGABILITY
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DOI：
10.1136/bmj.290.6466.428
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发表时间：
1985-01-01
影响因子：
105.7
通讯作者：
MILLER, GJ
中科院分区：
文献类型：
--
作者：
MEADE, TW;VICKERS, MV;MILLER, GJ
诺斯威克公园心脏研究的958名参与者确定了血小板聚集性的流行病学特征。主要的分析是基于ADP的剂量，当ADP的初次聚集发生在其最大速度的一半时。聚集性在两种性别中都随着年龄的增长而增加，白人比黑人(尤其是男性)的聚集能力更强，并随着习惯性饮酒水平的下降而下降。女性的聚集性高于男性，非吸烟者的聚集性高于吸烟者。一方面，聚集性与肥胖、当前或过去口服避孕药的使用、更年期状态或血液中胆固醇和甘油三酯浓度之间没有关系。在有缺血性心脏病病史的男性和有心电缺血证据的男性中，聚集能力略高于那些没有缺血性心脏病病史的男性，尽管不是很明显。血浆纤维蛋白原浓度和聚集性之间有很强的相关性。被广泛接受的血小板聚集性的概念及其含义可能过于简单化了。在预防血栓形成方面，考虑改变外界对血小板行为的影响，如血浆纤维蛋白原浓度或凝血酶的产生，可能与单纯依赖血小板激活剂一样有用。
The epidemiological characteristics of platelet aggregability were established in 958 participants in the Northwick Park Heart Study. The main analyses were based on the dose of ADP at which primary aggregation occurred at half its maximum velocity. Aggregability increased with age in both sexes, was greater in whites than blacks (particularly among men) and tended to decrease with the level of habitual alcohol consumption. Aggregability was greater in women than men and in non-smokers than smokers. There was no relation between aggregability on the one hand and obesity, current or past oral contraceptive use, menopausal state, or blood cholesterol and triglyceride concentrations on the other. Aggregability was somewhat, though not significantly, higher in men with a history of ischemic heart disease and in those with ECG evidence of ischemia than in those without. There was a strong association between the plasma fibrinogen concentration and aggregability. The widely held concept of platelet aggregability and its implications is probably an oversimplification. In the prevention of thrombosis it may be as useful to consider modifying external influences on platelet behavior, such as plasma fibrinogen concentration or thrombin production, as it is to rely solely on platelet active agents.