Catalytic asymmetric synthesis of α,α,α-trifluoromethylamines by the copper-catalyzed nucleophilic addition of diorganozinc reagents to imines
Catalytic asymmetric synthesis of α,α,α-trifluoromethylamines by the copper-catalyzed nucleophilic addition of diorganozinc reagents to imines
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DOI：
10.1021/ol0607847
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发表时间：
2006-06-22
期刊：
影响因子：
5.2
通讯作者：
Charette, Andre B.
中科院分区：
文献类型：
--
作者：
Lauzon, Caroline;Charette, Andre B.
本文报道了铜催化的二有机锌试剂与N-膦酰亚胺的不对称加成反应，合成了手性α，α，α-三氟甲基胺。由相应的半缩醛原位生成的三氟甲基酮亚胺以高产率（71-89%）和优异的对映体控制（91- 99%ee）得到手性酰胺。
A copper-catalyzed asymmetric addition of diorganozinc reagents to N-phosphinoylimines has been developed for the synthesis of chiral alpha, alpha, alpha-trifluoromethylamines. The trifluoromethyl ketimines, generated in situ from the corresponding hemiaminals, led to the chiral amides in high yields (71-89%) and excellent enantiocontrol (91-99% ee).