CARCINOMA-INSITU OF THE TESTIS - POSSIBLE ORIGIN FROM GONOCYTES AND PRECURSOR OF ALL TYPES OF GERM-CELL TUMORS EXCEPT SPERMATOCYTOMA
CARCINOMA-INSITU OF THE TESTIS - POSSIBLE ORIGIN FROM GONOCYTES AND PRECURSOR OF ALL TYPES OF GERM-CELL TUMORS EXCEPT SPERMATOCYTOMA
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DOI：
10.1111/j.1365-2605.1987.tb00161.x
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发表时间：
1987-02-01
影响因子：
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通讯作者：
MULLER, J
中科院分区：
文献类型：
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作者：
SKAKKEBAEK, NE;BERTHELSEN, JG;MULLER, J
基于形态学和组织化学研究以及临床经验的证据，提出了以下假设：（1）原位癌（CIS）生殖细胞是恶性生殖细胞;（2）这些CIS生殖细胞具有一定的能力退化为更原始的全能胚胎细胞，可引起所有类型的非恶性生殖细胞肿瘤;（3）典型卵巢癌的肿瘤生殖细胞是来自CIS生殖细胞的恶性生殖细胞，CIS生殖细胞已丧失退化为全能胚胎细胞的能力;（4）CIS生殖细胞退化为全能胚胎细胞的能力随着年龄的增长而下降，而形成经典精原细胞瘤细胞的能力却保留下来;（5）CIS生殖细胞转化为侵袭性肿瘤依赖于促性腺激素和/或睾丸类固醇等因素;（6）经典型和精细胞性卵巢癌的发病机制无关。由于这些假设，建议将其命名为原位癌、卵巢癌和无性细胞瘤。
Based on evidence from morphological and histochemical studies and from clinical experience, the following hypotheses are proposed: (1) carcinoma‐in‐situ (CIS) germ cells are malignant gonocytes; (2) these CIS gonocytes have some capacity to regress into more primitive, totipotent embryonic cells which can give rise to all types of nonseminomatous germ cell tumours; (3) the tumour germ cells of classical seminomas are malignant gonocytes derived from CIS gonocytes which have lost their ability to regress into totipotent embryonic cells; (4) the ability of CIS gonocytes to regress into totipotent embryonic cells decreases with age, whereas the capacity to form classical seminoma cells is preserved; (5) the transformation of CIS gonocytes into invasive tumours is dependent on factors such as gonadotrophins and/or testicular steroids; (6) the pathogenesis of classical and spermatocytic seminoma are unrelated.As a consequence of these hypotheses an alternative nomenclature for carcinoma‐in‐situ, seminoma and dysgerminoma is suggested.