Amino Acid Signatures to Evaluate the Beneficial Effects of Weight Loss.
Amino Acid Signatures to Evaluate the Beneficial Effects of Weight Loss.
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DOI：
10.1155/2017/6490473
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发表时间：
2017
影响因子：
2.8
通讯作者：
Ridderstråle M
中科院分区：
文献类型：
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作者：
Geidenstam N;Magnusson M;Danielsson APH;Gerszten RE;Wang TJ;Reinius LE;Mulder H;Melander O;Ridderstråle M
目标。我们调查了循环氨基酸水平与肥胖的关系；减肥后保持体重在多大程度上可以纠正氨基酸异常；以及氨基酸是否与减肥有关。方法：研究方法。来自马尔默饮食和癌症心血管队列(MDC-CC)的804名参与者研究了与腰围(WC)和体重指数(BMI)相关的氨基酸。分析了12名肥胖受试者在减肥和维持体重后氨基酸水平的变化，并在重复队列中进行了评估(n=83)。结果。在来自MDC-CC的8种与BMI相关的氨基酸中，丙氨酸、异亮氨酸、酪氨酸、苯丙氨酸和谷氨酸在体重减轻后减少，而天冬酰胺在体重维持后增加。这些变化在复制队列中得到了验证。根据肥胖相关氨基酸和已知危险因素构建的得分在≥减重10%组中降低，并伴随着体重指数的相关变化(R2=0.160.22p<；0.002)，而在减重10%组中得分上升(p<；0.0004)。结论。减肥后保持体重会导致与肥胖相关的氨基酸水平的不同变化。基于流行病学和干预性数据的治疗可修改评分可用于评估减肥的潜在代谢益处。
Aims. We investigated the relationship between circulating amino acid levels and obesity; to what extent weight loss followed by weight maintenance can correct amino acid abnormalities; and whether amino acids are related to weight loss. Methods. Amino acids associated with waist circumference (WC) and BMI were studied in 804 participants from the Malmö Diet and Cancer Cardiovascular Cohort (MDC-CC). Changes in amino acid levels were analyzed after weight loss and weight maintenance in 12 obese subjects and evaluated in a replication cohort (n = 83). Results. Out of the eight identified BMI-associated amino acids from the MDC-CC, alanine, isoleucine, tyrosine, phenylalanine, and glutamate decreased after weight loss, while asparagine increased after weight maintenance. These changes were validated in the replication cohort. Scores that were constructed based on obesity-associated amino acids and known risk factors decreased in the ≥10% weight loss group with an associated change in BMI (R2 = 0.16–0.22, p < 0.002), whereas the scores increased in the <10% weight loss group (p < 0.0004). Conclusions. Weight loss followed by weight maintenance leads to differential changes in amino acid levels associated with obesity. Treatment modifiable scores based on epidemiological and interventional data may be used to evaluate the potential metabolic benefit of weight loss.