Effects of continuous naloxone administration on ventral tegmental self-stimulation.
Effects of continuous naloxone administration on ventral tegmental self-stimulation.
复制标题
连续纳洛酮给药对腹侧被盖自我刺激的影响。
DOI：
10.1016/0006-8993(91)91250-5
复制
发表时间：
1991
期刊：
影响因子：
2.9
通讯作者：
Stein,EA
中科院分区：
文献类型：
--
作者：
Hawkins,M;Stein,EA
连续皮下注射纳洛酮(3 mg/kg/h)，可使腹侧被盖自刺激率-频率曲线右移，但不影响行为表现。此外，这种阿片受体的长期阻断改变了纳洛酮治疗动物的海马区和嗅结节中的μ结合参数。这些发现说明了阿片肽在大脑刺激奖赏的调节中所起的作用。
Continuous subcutaneous administration of naloxone (3 mg/kg/h), shifted ventral tegmental self-stimulation rate-frequency curves to the right, without suppressing behavioral performance. In addition this chronic blockade of opioid receptors altered μ binding parameters in the hippocampus and olfactory tubercle of naloxone-treated animals. These findings speak to the role opioid peptides play in the mediation of brain stimulation reward.