Association between Non-Alcoholic Steatohepatitis-Related Hepatocellular Carcinoma and Periodontopathic Bacteria: A Cross-Sectional Pilot Study
Association between Non-Alcoholic Steatohepatitis-Related Hepatocellular Carcinoma and Periodontopathic Bacteria: A Cross-Sectional Pilot Study
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DOI：
10.3390/app13063893
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发表时间：
2023-03
期刊：
影响因子：
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通讯作者：
Ryo Takuma;T. Morozumi;Yuko Yamamoto;Takashi Kobayashi;Takaaki Matsui;M. Yoneda;Takaomi Kessoku;Asako Nogami;M. Tamura;Yohei Kamata;Shuntaro Sugihara;Y. Nomura;M. To;M. Minabe;K. Mitsudo;A. Nakajima;M. Komaki
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文献类型：
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作者：
Ryo Takuma;T. Morozumi;Yuko Yamamoto;Takashi Kobayashi;Takaaki Matsui;M. Yoneda;Takaomi Kessoku;Asako Nogami;M. Tamura;Yohei Kamata;Shuntaro Sugihara;Y. Nomura;M. To;M. Minabe;K. Mitsudo;A. Nakajima;M. Komaki
随着代谢综合征因素的增加，非酒精性脂肪性肝炎（NASH）相关肝细胞癌（HCC）的发病率逐年增加。本研究旨在分析牙周致病菌在NASH相关肝细胞癌（NASH-HCC）中的作用。对40例NASH患者和20例NASH-HCC患者进行问卷调查、牙周检查、医学检查和标本采集（唾液、漱口水和外周血）。NASH-HCC组中针对牙龈卟啉单胞菌（p = 0.031）和具核梭杆菌（p = 0.003）的免疫球蛋白（IG）G抗体滴度显著高于NASH组。牙龈卟啉单胞菌和F. NASH-HCC组的F.核质比率有显著性差异（p = 0.009）。NASH-HCC组唾液细菌植物群的Shannon指数显著低于NASH组（p < 0.001）。NASH-HCC组唾液伊加浓度显著较低（p = 0.007），唾液伊加流速较慢（p = 0.003）。在所有参与者中，唾液伊加流速和F。核质比呈显著负相关（p = 0.02）。口腔牙龈卟啉单胞菌和F.有核细胞可能与NASH-HCC的发病有关，唾液伊加水平与F.具核的
The incidence of non-alcoholic steatohepatitis (NASH)-related hepatocellular carcinoma (HCC) is increasing annually as the metabolic syndrome factors increase. This study aimed to analyze the involvement of periodontopathic bacteria in NASH-related HCC (NASH-HCC). Questionnaire investigation, periodontal examination, medical examination, and specimen collection (saliva, mouth-rinsed water, and peripheral blood) were performed in 40 patients with NASH and in 20 patients with NASH-HCC. Immunoglobulin (Ig) G antibody titers against Porphyromonas gingivalis (p = 0.031) and Fusobacterium nucleatum (p = 0.003) were significantly higher in the NASH-HCC group than in the NASH group. P. gingivalis and F. nucleatum ratios were higher in the NASH-HCC group than in the NASH group; however, only F. nucleatum ratio was significant (p = 0.009). The Shannon index of salivary bacterial flora was significantly lower in the NASH-HCC group than in the NASH group (p < 0.001). The NASH-HCC group had a significantly lower salivary IgA concentration (p = 0.007) and a slower salivary IgA flow rate (p = 0.003). In all participants, the salivary IgA flow rate and the F. nucleatum ratio showed a significant negative correlation (p = 0.02). Oral P. gingivalis and F. nucleatum were possibly associated with NASH-HCC pathogenesis, and salivary IgA levels were correlated with F. nucleatum.