Reductive N-Formylation of Nitroarenes Mediated by Rongalite.
Reductive N-Formylation of Nitroarenes Mediated by Rongalite.
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DOI：
10.1021/acs.orglett.3c02839
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发表时间：
2023-09
期刊：
影响因子：
5.2
通讯作者：
Huai-yu Wang;Xiang-Long Chen;Chun-Yan Wu;Dong-Sheng Yang;Ting Chen;An-Xin Wu
中科院分区：
文献类型：
--
作者：
Huai-yu Wang;Xiang-Long Chen;Chun-Yan Wu;Dong-Sheng Yang;Ting Chen;An-Xin Wu
Herein, we disclose a straightforward approach to access transition-metal-free reductive N-formylation of nitroarenes. This reaction integrates the dual role of rongalite, which acts as a reductant and a C1 building block concurrently. This provides an alternative method for the synthesis of N-aryl formamides from nitroarenes, including the construction of a C-N bond. The utility of this protocol was demonstrated by scale-up synthesis and late-stage functionalizations of complex molecules.
