Functional tissue engineering parameters toward designing repair and replacement strategies
Functional tissue engineering parameters toward designing repair and replacement strategies
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DOI：
10.1097/01.blo.0000144585.65450.d2
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发表时间：
2004-10-01
影响因子：
4.2
通讯作者：
Hunter, SA
中科院分区：
文献类型：
--
作者：
Butler, DL;Shearn, JT;Hunter, SA
软组织损伤后引起的异常关节运动学和负荷被认为是导致长期退行性关节疾病和骨关节炎的原因。在修复和重建这些受损结构后，控制异常运动学似乎对限制关节软骨表面的磨损很重要。在本文中，我们建议扩展功能性组织工程的范例，以更充分地表征正常关节功能，并建立软组织修复和重建的设计参数，以最终保护手术后的关节表面。结构-功能关系的研究日益复杂的组织，从肌腱到肌腱。重点放在理解正常的组织在体内的功能，通过进行生物力学实验，在体外，更好地模拟在体内的条件。该过程产生九类功能性组织工程参数：不同的纤维长度，在体内的力和位移，相对附着部位位置的变化，从相邻结构的负载，纤维相互作用，插入类型，材料特性的区域变化，非平行纤维取向，和复杂的结构内的负载。这些功能性组织工程参数不仅有助于了解正常组织的功能，而且有助于更有效地设计其修复和替换。本文最后讨论了研究人员可能采取的研究方向，以建立组织特异性功能性组织工程参数，改善关节功能，减少关节面退化和骨关节炎。
Abnormal joint kinematics and loads induced after soft tissue injuries are assumed to contribute to long-term degenerative joint disease and osteoarthritis. Controlling abnormal kinematics after repair and reconstruction of these injured structures would seem to be important for limiting wear of the articular cartilage surfaces. In this paper, we propose to expand the paradigm of functional tissue engineering to more fully characterize normal joint function and to establish design parameters for soft tissue repair and reconstruction to ultimately protect joint surfaces after surgery. Structure-function relationships are examined for tissues of increasing complexity, from tendons to menisci. Emphasis is placed on understanding normal in vivo function of tissues by conducting biomechanical experiments in vitro that better mimic in vivo conditions. This process yields nine classes of functional tissue engineering parameters: differential fiber length, in vivo force and displacement, variations in relative attachment site locations, loading from adjacent structures, fiber interactions, types of insertion, regional variations in material properties, nonparallel fiber orientations, and complex loading within the structure. These functional tissue engineering parameters are useful not only for understanding the function of normal tissues but for more effectively designing their repair and replacement. This paper concludes with a discussion of research directions that investigators might take to establish tissue-specific functional tissue engineering parameters for improving joint function and reducing articular surface degradation and osteoarthritis.