Negative symptoms and hypofrontality in chronic schizophrenia.
Negative symptoms and hypofrontality in chronic schizophrenia.
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DOI：
10.1001/archpsyc.1992.01820120047007
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发表时间：
1992-12
影响因子：
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通讯作者：
A. Wolkin;M. Sanfilipo;A. Wolf;B. Angrist;J. Brodie;J. Rotrosen
中科院分区：
文献类型：
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作者：
A. Wolkin;M. Sanfilipo;A. Wolf;B. Angrist;J. Brodie;J. Rotrosen
额叶功能障碍被广泛怀疑是精神分裂症阴性症状的基础。这一假设主要基于对额叶病变和阴性症状影响之间相似性的长期观察。然而，在精神分裂症患者中，很少有直接证据表明这种关联。我们使用正电子发射断层扫描测量了20例慢性精神分裂症患者在接受扫描而未接受抗精神病药物治疗时，相对前额叶皮质葡萄糖代谢降低（前额叶功能减退）与阴性症状严重程度之间的关系。我们发现阴性症状和前额叶代谢减退之间有密切关系，特别是在右背外侧凸面。这种关联是区域性的。此外，没有证据表明这种关系是年龄、脑萎缩或阳性症状严重程度的人为因素。
Frontal lobe dysfunction is widely suspected to underlie negative symptoms of schizophrenia. This hypothesis is based largely on long-standing observations of the similarities between the effects of frontal lobe lesions and negative symptoms. However, there is little direct evidence specifically for such an association in schizophrenic patients. We measured the relationship between decreased relative prefrontal cortex glucose metabolism (hypofrontality) using positron emission tomography and evaluated the severity of negative symptoms in 20 chronic schizophrenics who underwent scanning while not receiving neuroleptic drugs. We found a close relationship between negative symptoms and prefrontal hypometabolism, particularly in the right dorsolateral convexity. This association was regionally specific. Furthermore, there was no evidence that this relationship was an artifact of age, cerebral atrophy, or severity of positive symptoms.