Upregulated PD-1 Expression Is Associated with the Development of Systemic Lupus Erythematosus, but Not the PD-1.1 Allele of the PDCD1 Gene.
Upregulated PD-1 Expression Is Associated with the Development of Systemic Lupus Erythematosus, but Not the PD-1.1 Allele of the PDCD1 Gene.
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PD-1 表达上调与系统性红斑狼疮的发生有关，但与 PDCD1 基因的 PD-1.1 等位基因无关
DOI：
10.1155/2014/950903
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发表时间：
2014
影响因子：
2.9
通讯作者：
Qian Q
中科院分区：
文献类型：
--
作者：
Jiao Q;Liu C;Yang Z;Ding Q;Wang M;Li M;Zhu T;Qian H;Li W;Tu N;Fang F;Ye L;Zhao Z;Qian Q
系统性红斑狼疮（SLE）是一种遗传复杂的多系统自身免疫性疾病。程序性死亡1（Programmed death 1，PD-1）是维持外周免疫耐受的负性T细胞调节因子，在与配体相互作用时向T细胞发出负性信号，是SLE发病的候选基因。为探讨PD-1的表达水平是否与SLE的发病机制有关，采用流式细胞术和实时定量逆转录聚合酶链反应（RT-PCR）检测30例SLE患者和30例对照者外周血单个核细胞（PBMC）中PD-1的表达水平。此外，PD-1表达水平是否与SNP rs36084323的变体和SLE疾病活动指数（SLEDAI）相关，在这项工作中进行了研究。SLE患者PD-1表达水平较健康对照组明显增高。SLE患者PD-1表达水平的上调与SLEDAI评分密切相关。在PD-1表达水平和SNP rs36084323之间未发现显著差异。结果提示PD-1的高表达可能与SLE的发病机制有关，PD-1的高表达可能是SLE诊断的一个生物标志物，PD-1抑制剂可能有助于SLE的治疗。
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with complicated genetic inheritance. Programmed death 1 (PD-1), a negative T cell regulator to maintain peripheral tolerance, induces negative signals to T cells during interaction with its ligands and is therefore a candidate gene in the development of SLE. In order to examine whether expression levels of PD-1 contribute to the pathogenesis of SLE, 30 patients with SLE and 30 controls were recruited and their PD-1 expression levels in peripheral blood mononuclear cells (PBMCs) were measured via flow cytometry and quantitative real-time-reverse transcription polymerase chain reaction (RT-PCR). Also, whether PD-1 expression levels are associated with the variant of the SNP rs36084323 and the SLE Disease Activity Index (SLEDAI) was studied in this work. The PD-1 expression levels of SLE patients were significantly increased compared with those of the healthy controls. The upregulated PD-1 expression levels in SLE patients were greatly associated with SLEDAI scores. No significant difference was found between PD-1 expression levels and SNP rs36084323. The results suggest that increased expression of PD-1 may correlate with the pathogenesis of SLE, upregulated PD-1 expression may be a biomarker for SLE diagnosis, and PD-1 inhibitor may be useful to SLE treatment.
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影响因子：
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作者：
Prokunina, L;Padyukov, L;Alarcón-Riquelme, M
通讯作者：
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影响因子：
3.5
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通讯作者：
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