Profiling of hla-B alleles for association studies with ankylosing spondylitis in the chinese population.
Profiling of hla-B alleles for association studies with ankylosing spondylitis in the chinese population.
复制标题
DOI：
10.2174/1874312920130628001
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Zhou X
中科院分区：
文献类型：
--
作者：
Yi L;Wang J;Guo X;Espitia MG;Chen E;Assassi S;Jin L;Zou H;Reveille JD;Zhou X
人类白细胞抗原（HLA）B*27是强直性脊柱炎（AS）的易感等位基因。然而，AS相关的HLA-B*27和其他HLA-B等位基因的主要亚型在不同种族人群中存在差异。在此，我们检测了360例AS患者和350例对照的HLA-B等位基因。采用基于序列的分型（SBT）方法进行HLA-B基因分型。在队列中观察到6种HLA-B *27亚型B*27：04、B* 27：05、B* 27：07、B* 27：08、B*27：10和B*27：15。HLA-B*27：04：01和-B*27：05：02等位基因在AS患者中明显增高，是AS的两个主要易感等位基因。仅在AS患者中观察到纯合子B*27。在这些研究中发现了30个HLA-B等位基因。HLA-B *15，尤其是B*15：01：01，在中国人中占优势。中国AS患者中常见的HLA-B等位基因如HLA-B*15、B*13、B*46和B*51均明显减少。总之，本研究分析了HLA-B等位基因，并确定了B27在中国汉族人群中的主要易感亚型
Human leucocyte antigen (HLA) B*27 is a susceptibility allele to ankylosing spondylitis (AS). However, major AS-associated subtypes of HLA-B*27 and other HLA-B alleles vary in different ethnic populations. Herein, we examined HLA-B alleles in a total of 360 AS patients and 350 controls of Chinese Han ancestry. The HLA-B genotyping was performed with sequence-based typing (SBT) method. Six HLA-B*27 subtypes B*27:04, B*27:05, B*27:07, B*27:08, B*27:10 and B*27:15 were observed in the cohorts. HLA-B*27:04:01 and -B*27:05:02 appeared significantly increased in AS patients, which indicated as two major susceptibility alleles to AS. Homozygous B*27 was observed only in AS patients. There are 30 HLA-B alleles identified in the studies. HLA-B*15, especially B*15:01:01:01, appeared as the major allele type in the Chinese controls. Some common HLA-B alleles such as HLA-B*15, B*13, B*46 and B*51 were significantly reduced in Chinese AS patients. In conclusion, the studies profiled the HLA-B alleles, and identified major susceptibility subtypes of B27 to AS in Han Chinese population