Controlled induction, enhancement, and guidance of neuronal growth cones by use of line optical tweezers
Controlled induction, enhancement, and guidance of neuronal growth cones by use of line optical tweezers
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DOI：
10.1364/ol.30.002596
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发表时间：
2005-10-01
期刊：
影响因子：
3.6
通讯作者：
Gupta, PK
中科院分区：
文献类型：
--
作者：
Mohanty, SK;Sharma, M;Gupta, PK
我们报告了一种基于光镊的方法，用于有效和受控地操纵神经元生长锥。该方法利用直线光镊中产生的不对称横向梯度力将肌动蛋白单体沿所需的生长方向运输。通过这种方法，已经实现了从神经元细胞体诱导人工生长锥并提高自然生长锥的生长速率。还讨论了使用这种方法使两个生长锥靠近以建立神经元连接。 (c) 2005 年美国光学学会。
We report an optical tweezers based approach for efficient and controlled manipulation of neuronal growth cones. The approach exploits asymmetric transverse gradient force created in a line optical tweezers to transport actin monomers in the desired growth direction. With this approach induction of artificial growth cones from the neuronal cell body and enhancement of the growth rate of the natural growth cones have been achieved. The use of this approach to bring two growth cones into close proximity for establishing a neuronal connection is also discussed. (c) 2005 Optical Society of America.