SIMIAN SARCOMA-VIRUS ONC GENE, V-SIS, IS DERIVED FROM THE GENE (OR GENES) ENCODING A PLATELET-DERIVED GROWTH-FACTOR
SIMIAN SARCOMA-VIRUS ONC GENE, V-SIS, IS DERIVED FROM THE GENE (OR GENES) ENCODING A PLATELET-DERIVED GROWTH-FACTOR
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DOI：
10.1126/science.6304883
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发表时间：
1983-01-01
期刊：
影响因子：
56.9
通讯作者：
ANTONIADES, HN
中科院分区：
文献类型：
--
作者：
DOOLITTLE, RF;HUNKAPILLER, MW;ANTONIADES, HN
灵长类肉瘤病毒的转化蛋白和血小板衍生生长因子衍生自相同或密切相关的细胞基因。这一结论是基于来源于猿肉瘤病毒onc基因的转化蛋白v-sis和人血小板衍生生长因子之间的广泛序列相似性的证明。v-sis转化细胞的机制可能涉及一种蛋白质的组成型表达，该蛋白质的功能与正常细胞生长过程中瞬时活跃的因子的功能相似或相同。
The transforming protein of a primate sarcoma virus and a platelet-derived growth factor are derived from the same or closely related cellular genes. This conclusion is based on the demonstration of extensive sequence similarity between the transforming protein derived from the simian sarcoma virus onc gene, v-sis, and a human platelet-derived growth factor. The mechanism by which v-sis transforms cells could involve the constitutive expression of a protein with functions similar or identical to those of a factor active transiently during normal cell growth.