Experimental fluorescence tomography of tissues with noncontact measurements
Experimental fluorescence tomography of tissues with noncontact measurements
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DOI：
10.1109/tmi.2004.825633
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发表时间：
2004-04
影响因子：
10.6
通讯作者：
R. Schulz;J. Ripoll;V. Ntziachristos
中科院分区：
文献类型：
--
作者：
R. Schulz;J. Ripoll;V. Ntziachristos
从漫射介质的非接触式光学测量可以促进在多个角度使用大型检测器阵列，这非常适合于漫射光学层析成像应用。这种成像策略可以消除对与组织接触的单个纤维、受限几何形状和匹配流体的需要。因此，它可以显着改善实验程序，提高我们的能力，可视化功能和分子过程中的体内。在本文中，我们描述了这种新概念的实验实施，并证明了执行小动物成像的能力。
Noncontact optical measurements from diffuse media could facilitate the use of large detector arrays at multiple angles that are well suited for diffuse optical tomography applications. Such imaging strategy could eliminate the need for individual fibers in contact with tissue, restricted geometries, and matching fluids. Thus, it could significantly improve experimental procedures and enhance our ability to visualize functional and molecular processes in vivo. In this paper, we describe the experimental implementation of this novel concept and demonstrate capacity to perform small animal imaging.