ABO Blood Group and Outcomes in Patients with COVID-19 Admitted in the Intensive Care Unit (ICU): A Retrospective Study in a Tertiary-Level Hospital in Bangladesh.
ABO Blood Group and Outcomes in Patients with COVID-19 Admitted in the Intensive Care Unit (ICU): A Retrospective Study in a Tertiary-Level Hospital in Bangladesh.
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DOI：
10.2147/jmdh.s330958
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发表时间：
2021
影响因子：
3.3
通讯作者：
Hawlader MDH
中科院分区：
文献类型：
--
作者：
Halim MR;Saha S;Haque IU;Jesmin S;Nishat RJ;Islam ASMDA;Roy S;Haque MMA;Islam MM;Hamid T;Ahmed KN;Talukder MAI;Ahmed A;Hasan E;Ananna N;Mohsin FM;Hawlader MDH
全球受COVID-19疫情严重影响已超过一年，迄今确诊病例超过1. 91亿例，死亡人数超过410万。之前的研究已经探索了2019冠状病毒病（COVID-19）的几个风险因素，但仍然缺乏与ABO血型的关联。这项研究旨在找出ABO血型与孟加拉国COVID-19结果之间的关系。这项回顾性横断面研究于2020年4月至2020年11月在孟加拉国达卡市一家三级COVID专用医院的重症监护室（ICU）进行。提取了771名重症患者的记录，这些患者通过逆转录酶-聚合酶链反应（RT-PCR）检测确诊为COVID-19，健康记录中有血型记录。血型分布以A型占37.35%，B型占17.38%，AB型占26.46%，O型占18.81%。临床症状在A型血患者中更常见（p < 0.05）。A型血患者的WBC计数和血清铁蛋白峰值水平较高，两者均具有统计学显著性（p < 0.001）。A型血患者需要更多的辅助供氧，与其他血型患者相比，A型血患者更容易死亡（p < 0.05）。在多变量分析中，我们的主要结局死亡与A型血显著相关（AOR：3.49，95%CI：1.57-7.73），同时调整了年龄、男性性别和非传染性疾病。根据这项研究结果，可以得出结论，A型血的COVID-19患者死亡和其他并发症的几率更高。作者建议在治疗COVID-19患者之前进行血型鉴定，医护人员应根据这一结果优先治疗患者。
The world is heavily suffering from the COVID-19 pandemic for more than a year, with over 191 million confirmed cases and more than 4.1 million deaths to date. Previous studies have explored several risk factors for coronavirus disease 2019 (COVID-19), but there is still a lack of association with ABO blood type. This study aimed to find out the relationship between the ABO blood group and COVID-19 outcomes in Bangladesh. This retrospective cross-sectional study was conducted in the intensive care unit (ICU) of a tertiary-level COVID-dedicated hospital in Dhaka city, Bangladesh, between April 2020 and November 2020. Records from 771 critically ill patients were extracted who were confirmed for COVID-19 by reverse transcriptase-polymerase chain reaction (RT-PCR) assay, and blood grouping records were available in the health records. The blood groups were 37.35%, 17.38%, 26.46%, and 18.81% for A, B, AB, and O type, respectively. Clinical symptoms were significantly more common in patients with blood type A (p < 0.05). Patients with blood type A had higher WBC counts and peak serum ferritin levels and both were statistically significant (p < 0.001). Patients with blood type A had a greater need for supplemental oxygen, and they were more likely to die in comparison to the patients with other blood types (p < 0.05). In multivariable analysis, our primary outcome death was significantly associated with blood type A (AOR: 3.49, 95% CI: 1.57–7.73) while adjusting for age, male gender, and non-communicable diseases. Based on this study results, it can be concluded that the COVID-19 patients with blood type A have a higher chance of death and other complications. The authors recommend blood grouping before treating the COVID-19 patients, and healthcare workers should prioritize treating the patients based on that result.