Anemia and the frail elderly
Anemia and the frail elderly
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DOI：
10.1053/j.seminhematol.2008.06.002
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发表时间：
2008-10-01
影响因子：
3.6
通讯作者：
Artz, Andrew S.
中科院分区：
文献类型：
--
作者：
Artz, Andrew S.
虚弱是一种易受压力影响的临床综合征，主要发生在老年人中，与生理储备受损有关。虚弱的特征包括体重减轻、疲惫、肌无力、运动能力受损和认知减慢，可独立于共病状况进行识别。在体弱的老年人中，贫血的患病率明显增加，贫血和体弱之间的相互作用是复杂的，自信地分离因果关系可能是不可能的。然而，贫血作为一个强大的预后因素的发展与脆弱相关的问题，如肌肉无力，性能下降，福尔斯，和死亡率。此外，血红蛋白轻度减少与不良结局有相似的相关性，该数据强烈暗示贫血易诱发或加速虚弱的发展。迫切需要进行干预性研究，以确定治疗是否可以减轻虚弱的发展和/或虚弱的红杉。
Frailty engenders a recognizable clinical syndrome of vulnerability to stressors related to impaired physiologic reserve that primarily occurs among older adults, Features of frailty Include weight loss, exhaustion, muscle weakness, performance Impairment, and cognitive slowing and can be Identified Independent of comorbid conditions. Among frail older adults, anemia prevalence Is markedly Increased, The Interaction between anemia and frailty Is complex and confidently separating cause and effect may not be possible. Nevertheless, anemia functions as a powerful prognostic factor for the development of frailty related problems such as muscle weakness, reduced performance, falls, and mortality. Further, mildly reduced hemoglobin shows a similar association with adverse outcomes, The date strongly Intimate that anemia predisposes or accelerates the development of frailty. Anemia Interventional studies are sorely needed to determine whether treatment may mitigate either the development of frailty and/or the sequoia of frailty.