Denervation resulting in dento-alveolar ankylosis associated with decreased Malassez epithelium
Denervation resulting in dento-alveolar ankylosis associated with decreased Malassez epithelium
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DOI：
10.1177/154405910408300808
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发表时间：
2004-08-01
影响因子：
7.6
通讯作者：
Takano-Yamamoto, T
中科院分区：
文献类型：
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作者：
Fujiyama, K;Yamashiro, T;Takano-Yamamoto, T
下肺泡神经去神经支配导致马拉塞氏上皮细胞分布明显减少。为了探讨马拉塞上皮的作用，我们试图通过实验性去神经控制来评估该上皮周围的牙槽组织可能发生的变化。我们发现去神经支配导致牙齿-牙槽强直，牙周间隙宽度减小。有趣的是，在去神经支配10周后，随着马拉塞上皮的再生，牙周间隙宽度相应显著增加。这些发现提示Malassez上皮可能参与牙周间隙的维持，感觉神经支配可能与之间接相关。此外，令人感兴趣的是，去神经支配激活了冠状根表面的根吸收，因此被吸收的腔隙被细胞骨质修复。提示Malassez上皮可能负调控根吸收，诱导脱细胞骨质形成。
Inferior alveolar nerve denervation causes appreciable decreases in the distribution of epithelial rests of Malassez. To explore roles of the Malassez epithelium, we attempted to evaluate possible changes in dento-alveolar tissues surrounding this epithelium by experimental denervation. We found that denervation led to dento-alveolar ankylosis with a decrease in the width of the periodontal spaces. Interestingly, with regeneration of the Malassez epithelium 10 weeks after the denervation, the periodontal space width showed a correspondingly significant increase. These findings suggest that the Malassez epithelium may be involved in the maintenance of periodontal space and that sensory innervation might be indirectly associated with it. In addition, it is of interest that denervation activated root resorption of the coronal root surface and that the consequently resorbed lacunae were repaired by cellular cementum. It is suggested that Malassez epithelium may negatively regulate root resorption and induce acellular cementum formation.