FOCAL ELECTROENCEPHALOGRAPHIC SEIZURE DISCHARGES IN ACUTE CEREBRAL INFARCTION - ELECTROGRAPHIC CLINICAL AND PATHOLOGICAL OBSERVATIONS
FOCAL ELECTROENCEPHALOGRAPHIC SEIZURE DISCHARGES IN ACUTE CEREBRAL INFARCTION - ELECTROGRAPHIC CLINICAL AND PATHOLOGICAL OBSERVATIONS
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DOI：
10.1212/wnl.15.2.123
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发表时间：
1965-01-01
期刊：
影响因子：
9.9
通讯作者：
LUTTRELL, CN
中科院分区：
文献类型：
--
作者：
CHATRIAN, GE;SHAW, CM;LUTTRELL, CN
对10例急性脑梗塞患者的脑电记录到局灶性惊厥放电。7例患者有反复的周期性偏侧癫痫样放电，3例患者在发作间期有不同程度的脑电慢波干扰。临床表现为癫痫发作伴脑电发作7例。6例出现局灶性运动现象，1例无反应。1例为“持续性精神发作”，2例在整个记录过程中处于昏迷状态，脑电发作与S临床症状无明显变化。在癫痫发作之间，所有受试者都表现出神经和精神功能受损的各种症状和体征，如意识、运动和感觉障碍的改变，视野缺陷，以及象征功能的改变。全身代谢紊乱(尿毒症和液体、电解质和酸碱平衡紊乱)可能通过降低大脑的惊厥阈值而导致7名患者癫痫发作的发生。6名患者从他们的急性疾病中康复。死亡的4人中有3人进行了尸检。脑电、临床和病理结果的相关性表明，癫痫放电发生在病变周围或周围的病理异常。
Focal seizure discharges were recorded in electroencephalograms of 10 subjects suffering from acute cerebral infarction. Seven patients had unremitting periodic lateralized epileptiform discharges ("PLEDs"), and 3 had varying degrees of slow disturbance in their electroencephalogram in intervals between seizures. Clinical manifestations of seizure activity accompanied the electroencephalographic paroxysms in 7 patients. The seizures consisted of focal motor phenomena in 6 and unresponsiveness in 1. In 1 patient with "continual psychical seizures" and in 2 who were comatose throughout the recording, the electroencephalographic seizures occurred without significant changes in the patient''s clinical condition. Between seizures all subjects exhibited various symptoms and signs of impaired neurological and mental functions, such as alterations of consciousness, motor and sensory deficits, visual field defects, and alterations of symbolic functions. Systemic metabolic disorders (uremia and disorders of fluid, electrolyte, and acid-base balance) may have contributed to the occurrence of epileptic seizures in 7 patients by lowering the convulsive threshold of the brain. Six patients recovered from their acute illness. Autopsy was obtained in 3 of 4 who died. Correlation of electroencephalographic, clinical, and pathological findings suggests that the seizure discharges arose peripheral to the lesion or to the surrounding pathological abnormalities.