EndothelinB (ETB) receptor‐activated potentiation of cholinergic nerve‐mediated contraction in human bronchus
EndothelinB (ETB) receptor‐activated potentiation of cholinergic nerve‐mediated contraction in human bronchus
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DOI：
10.1111/j.1476-5381.1996.tb15617.x
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发表时间：
1996-08
影响因子：
7.3
通讯作者：
L. Fernandes;P. Henry;P. Rigby;R. Goldie
中科院分区：
文献类型：
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作者：
L. Fernandes;P. Henry;P. Rigby;R. Goldie
在人离体支气管制备物中，内皮素B（ETB）受体选择性激动剂sarafotoxin S6 c（Stx 6c; 1 nM）可将0.5 - 1 Hz电场刺激（EFS）引起的神经介导收缩从19±4%增加至42±7%（n = 9）。在存在ETB受体选择性拮抗剂BQ-788（10 μm）的情况下，该作用被阻断。这些数据与一些动物种属中的发现一致，即ET-1和相关肽对胆碱能系统具有显著的神经调节作用。此外，它们为ET-1可能在哮喘的支气管阻塞中具有介导作用的概念提供了额外的支持。
In human isolated bronchial preparations, the endothelinB (ETB) receptor‐selective agonist, sarafotoxin S6c (Stx6c; 1 nM) increased nerve‐mediated contraction in response to electrical field stimulation (EFS) at 0.5‐1 Hz from 19±4% to 42±7% (n = 9). This effect was blocked in the presence of the ETB receptor‐selective antagonist, BQ‐788 (10 μm). These data are consistent with findings in some animal species that ET‐1 and related peptides have marked neuromodulatory influences on the cholinergic system. Furthermore, they provide additional support for the concept that ET‐1 may have a mediator role in bronchial obstruction in asthma.