Hyperprogression After Immune-Checkpoint Inhibitor Treatment: Characteristics and Hypotheses
Hyperprogression After Immune-Checkpoint Inhibitor Treatment: Characteristics and Hypotheses
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DOI：
10.3389/fonc.2020.00515
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发表时间：
2020
影响因子：
4.7
通讯作者：
Fan Songqing
中科院分区：
文献类型：
--
作者：
Zang Hongjing;Peng Jinwu;Zheng Hongmei;Fan Songqing
Immunotherapies in tumors have attracted increasing attention. They play an important role in precision medicine. Many immune-checkpoint inhibitors (ICIs) have obtained FDA approval and show good performance in the clinic. Hyperprogressive disease (HPD) after ICIs was first described in November 2016. Since then, a series of cases of HPD after ICIs have been reported. Notwithstanding that only a small subset of patients may experience this atypical response, HPD in affected patients means shorter survival times and worse prognoses. We summarized common standards for HPD diagnosis and profiled advantages and disadvantages. Elderly age, MDM2 family amplification, infiltration of PD-1-positive regulatory effector T cells and M2-like macrophages, and cancer stem cells may take part in HPD occurrence. Overall, we should focus on investigating the early markers and pathogenic mechanisms of HPD to solve this issue in ICIs.
