Characterization of the neuronal changes in the medial prefrontal cortex during jaw movement and in the eyeblink Pavlovian conditioning in the rabbit
Characterization of the neuronal changes in the medial prefrontal cortex during jaw movement and in the eyeblink Pavlovian conditioning in the rabbit
复制标题
DOI：
10.1016/s0166-4328(01)00410-7
复制
发表时间：
2002-05-14
影响因子：
2.7
通讯作者：
White, JD
中科院分区：
文献类型：
--
作者：
McLaughlin, J;Powell, DA;White, JD
内侧前额叶（mPFC）的单单位活动进行了评估，在防御（眨眼，EB）和食欲（下颌运动，JM）巴甫洛夫条件反射的兔子。还评估了伴随心率（HR）变化。在第一个实验中，强大的JM条件反射（CR），观察到一个色调水（CS+）的应急，但不色调单独（CS-），表明歧视JM条件。然而，CS诱发的加速HR反应没有区分性。然而，几个单一的单位放电模式都引起的音调-水和音调-单独，其中许多是唯一相关的CS +或CS -在第二个实验中，三个独立的刺激，包括音调，然后眶周休克（音调休克），水（音调-水），和白色噪音没有其次是休克或水，在相同的范例。观察到条件JM、EB和HR变化的辨别，即这些行为反应中的每一个都与相关CS呈现唯一相关。在第一次训练中，通过音调水诱发条件性心动过缓，随着进一步训练，条件性心动过缓变为心动过速。然而，条件性心动过缓诱发的音调休克整个训练。不同亚群的mPFC细胞被激活的音休克和音水意外事件，但一小群细胞被激活。(C)2002 Elsevier Science B. V.保留所有权利。
Medial prefrontal (mPFC) single-unit activity was assessed in defensive (eyeblink, EB) and appetitive (jaw movement, JM) Pavlovian conditioning in the rabbit. Concomitant heart rate (HR) changes were also assessed. In a first experiment robust JM conditioned responses (CRs) were observed to a tone-water (CS+) contingency but not to tone-alone (CS-), indicating discriminative JM conditioning. However, the CS-evoked accelerative HR response was not discriminative. Nevertheless, several single-unit discharge patterns were evoked by both tone-water and tone-alone, many of which were uniquely associated with either the CS + or CS - In a second experiment, Three separate stimuli, consisting of tone followed by periorbital shock (tone-shock), water (tone-water), and white noise not followed by shock or water, were presented in the same paradigm. Discrimination of conditioned JM, EB and HR changes were observed, i.e. each of these behavioral responses were uniquely associated with the relevant CS presentation. Conditioned bradycardia was evoked by tone-water during the first training session, which changed to tachycardia with further training. However, conditioned bradycardia was evoked by tone-shock throughout training. Different subpopulations of mPFC cells were activated by the tone-shock and tone-water contingencies, but a small group of cells were activated by both. (C) 2002 Elsevier Science B.V. All rights reserved.