Decrease in toe pinch force in male type 2 diabetic patients with diabetic nephropathy
Decrease in toe pinch force in male type 2 diabetic patients with diabetic nephropathy
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DOI：
10.1007/s10157-017-1507-5
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发表时间：
2018-06-01
影响因子：
2.3
通讯作者：
Tanaka, Satoshi
中科院分区：
文献类型：
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作者：
Kataoka, Hiroaki;Miyatake, Nobuyuki;Tanaka, Satoshi
本横断面研究的目的是调查2型糖尿病合并糖尿病肾病患者的脚趾捏力（TPF），并阐明影响TPF的因素。74例男性糖尿病肾病患者（年龄：62.7 ± 8.9岁，糖尿病病程：14.2 ± 8.6年）入选。根据糖尿病肾病分期，比较正常白蛋白尿组、微量白蛋白尿组和显性肾病组的TPF和伸膝力（KEF）。此外，我们还对影响TPF和KEF的因素进行了多元回归分析，正常白蛋白尿组、微量白蛋白尿组和显性肾病组分别有26、25和23例患者。显性肾病组的TPF（3.15 ± 0.75 kg）显著低于正常白蛋白尿组（4.2 ± 0.7 kg，p < 0.001）和微量白蛋白尿组（3.65 ± 0.81 kg，p = 0.022）。显性肾病组的KEF（37.1 ± 8.3 kgf）显著低于正常白蛋白尿组（44.8 ± 8.3 kgf，p = 0.010）。多元回归分析显示糖尿病多发性神经病（DPN）和糖尿病肾病是TPF的决定因素，年龄、体重指数和糖尿病肾病是KEF的决定因素，男性糖尿病肾病患者TPF和KEF随糖尿病肾病的进展而降低。此外，我们的研究结果表明，糖尿病肾病和DPN是关键参与减少TPF和KEF。
The purpose of this cross-sectional study was to investigate the toe pinch force (TPF) of type 2 diabetic patients with diabetic nephropathy by disease stage, and to clarify the factors affecting the TPF.Seventy-four men with diabetic nephropathy (age: 62.7 +/- 8.9 years, duration of diabetes: 14.2 +/- 8.6 years) were enrolled. According to the staging of diabetic nephropathy, TPF and knee extension force (KEF) were compared among three groups: normoalbuminuria, microalbuminuria, and overt nephropathy. In addition, we investigated factors influencing TPF and KEF by performing multiple regression analysis.Normoalbuminuria group, microalbuminuria group, and overt nephropathy group included 26, 25, and 23 patients, respectively. The TPF of the overt nephropathy group (3.15 +/- 0.75 kg) was significantly lower than that of the normoalbuminuria (4.2 +/- 0.7 kg, p < 0.001) and microalbuminuria groups (3.65 +/- 0.81 kg, p = 0.022). The KEF of the overt nephropathy group (37.1 +/- 8.3 kgf) was significantly lower than that of the normoalbuminuria group (44.8 +/- 8.3 kgf, p = 0.010). Multiple regression analysis revealed that diabetic polyneuropathy (DPN) and diabetic nephropathy were determinant factors of the TPF; and age, body mass index, and diabetic nephropathy were determinant factors of the KEF.We found in male patients with diabetic nephropathy, the TPF and KEF decreased with progression of diabetic nephropathy. Furthermore, our findings suggest diabetic nephropathy and DPN are critically involved in the reduction of TPF and KEF.