In vivo induction of T-follicular helper cells by modulation of regulatory T cell function.
In vivo induction of T-follicular helper cells by modulation of regulatory T cell function.
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通过调节调节性 T 细胞功能体内诱导滤泡辅助 T 细胞。
DOI：
10.1007/978-1-4939-2498-1_7
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
S.
中科院分区：
文献类型：
--
作者：
Wing ;JB. Sakaguchi;S.
调节性T细胞，特别是其滤泡常驻亚群T-滤泡调节性细胞，在维持免疫稳态和防止T-滤泡辅助细胞的扩增中起着关键作用。这些细胞使用的关键机制之一是CTLA-4依赖性炎症抑制。在本章中，我们详细介绍了接种疫苗后通过消耗Treg细胞（通过Foxp3连接的白喉毒素受体）或使用抗体阻断CTLA-4功能来增加t滤泡辅助细胞形成的方法。
Regulatory T cells, particularly their follicular resident subset, T-follicular regulatory cells, play a critical role in the maintenance of immune homeostasis and prevention of the expansion of T-follicular helper cells. One of the key mechanisms used by these cells is CTLA-4 dependent suppression of inflammation. In this chapter, we detail methods to increase the formation of T-follicular helper cells following vaccination by either depleting Treg cells, via Foxp3 linked diphtheria toxin receptor, or blocking CTLA-4 function by the use of antibodies.