Evidence for a general face salience signal in human amygdala
Evidence for a general face salience signal in human amygdala
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DOI：
10.1016/j.neuroimage.2010.11.024
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发表时间：
2011-02-14
期刊：
影响因子：
5.7
通讯作者：
Meyer-Lindenberg, Andreas
中科院分区：
文献类型：
--
作者：
Santos, Andreia;Mier, Daniela;Meyer-Lindenberg, Andreas
在面孔处理的社会神经科学中，杏仁核扮演着多种角色：恐惧/威胁刺激的信号，情绪表达和一般的显着性。目前的研究旨在直接比较杏仁核激活归因于这些条件的杏仁核反应匹配的情绪（威胁和非威胁）和非情绪的显着面孔在视觉搜索范式使用卡通面孔。参与者（21名健康志愿者）必须在一系列密切匹配的非目标面孔中检测目标面孔（愤怒，快乐，蓝色，红色，具有完全相同的特征）。行为结果显示，所有目标相比，非目标的弹出效果，表明他们都是突出的，独立的情绪或非情绪。虽然显著的杏仁核激活获得了所有的试验与突出的面孔（相比，那些只包含非目标的面孔），没有显着差异的激活之间出现的情绪威胁，情绪非威胁性，和非情绪的目标。此外，右侧和左侧杏仁核激活的目标试验被发现与目标检测的行为措施。这些研究结果提供了证据杏仁核的信号显着性的视觉搜索独立的方式的一般作用。鉴于杏仁核在几种神经精神疾病中的重要参与，目前的研究结果可能有助于我们进一步了解这些疾病中功能障碍的神经回路。(C)2010年爱思唯尔公司All rights reserved.
In the social neuroscience of face processing, multiple roles are attributed to amygdala: signalling of fear/threat-stimuli, of emotional expression, and general salience. The current study aimed at a direct comparison of amygdala activation attributable to these conditions by contrasting amygdala responses to matched emotional (threatening and non-threatening) and of non-emotional salient faces in a visual search paradigm using cartoon faces. Participants (21 healthy volunteers) had to detect a target face (angry, happy, blue, red, differing in the exact same features) in an array of closely matched non-target faces. Behavioural results revealed a pop-out effect for all targets compared to non-targets, indicating that they were all salient, independently of being emotional or non-emotional. While significant amygdala activation was obtained for all trials with salient faces (compared to those containing only non-target faces), no significant differences in activation emerged between emotional threatening, emotional non-threatening, and non-emotional targets. Moreover, right and left amygdala activation for target trials was found correlated to the behavioural measure of target detection. These findings provide evidence for a general role of the amygdala in signalling salience in a visual search independent of modality. Given the critical involvement of the amygdala in several neuropsychiatric disorders, the current findings may contribute to further our understanding on dysfunctional neural circuits in these disorders. (C) 2010 Elsevier Inc. All rights reserved.