Testing for Hardy Weinberg Equilibrium in national household surveys that collect family-based genetic data.
Testing for Hardy Weinberg Equilibrium in national household surveys that collect family-based genetic data.
复制标题
在收集基于家庭的遗传数据的国家家庭调查中测试哈迪温伯格平衡。
DOI：
10.1111/j.1469-1809.2011.00680.x
复制
发表时间：
2011
影响因子：
1.9
通讯作者：
Graubard,BarryI
中科院分区：
文献类型：
--
作者：
Li,Yan;Li,Zhaohai;Graubard,BarryI
In population‐based household surveys, for example, the National Health and Nutrition Examination Survey (NHANES), blood‐related individuals are often sampled from the same household. Therefore, genetic data collected from national household surveys are often correlated due to two levels of clustering (correlation) with one induced by themultistage geographical cluster sampling, and the other induced bybiological inheritance among multiple participants within the same sampled household. In this paper, we develop efficient statistical methods that consider the weighting effect induced by the differential selection probabilities in complex sample designs, as well as the clustering (correlation) effects described above. We examine and compare the magnitude of each level of clustering effects under different scenarios and identify the scenario under which the clustering effect induced by one level dominates the other. The proposed method is evaluated via Monte Carlo simulation studies and illustrated using the Hispanic Health and Nutrition Survey (HHANES) with simulated genotype data.
