Viral infections associated with oral cancers and diseases in the context of HIV: a workshop report
Viral infections associated with oral cancers and diseases in the context of HIV: a workshop report
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DOI：
10.1111/odi.12418
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发表时间：
2016-04-01
期刊：
影响因子：
3.8
通讯作者：
Moscicki, A-B
中科院分区：
文献类型：
--
作者：
Speicher, D. J.;Ramirez-Amador, V.;Moscicki, A-B
人疱疹病毒（HHV）和人乳头瘤病毒（HPV）在一般人群中很常见，在免疫功能正常的人群中，大多数无症状携带。然而，一旦一个人因年龄、疾病或艾滋病毒感染而免疫功能低下，这些休眠的病毒就会显现并产生疾病。在HIV阳性患者中，HHV和HPV感染引起的疾病以及由Epstein-Barr病毒、HHV-8和HPV引起的肿瘤病毒引起的癌症的风险增加。该研讨会研究了四个问题，涉及艾滋病毒阳性和阴性人群中与口腔癌和疾病相关的病毒，免疫反应以及用于准确诊断这些感染及其后遗症的生物标志物。每位发言者都指出了需要进一步研究的一些关键领域。
Human herpesviruses (HHVs) and human papillomavirus (HPV) are common in the general population and, in immunocompetent people, are mostly carried asymptomatically. However, once an individual becomes immunocompromised by age, illness or HIV infection these dormant viruses can manifest and produce disease. In HIV-positive patients, there is an increased risk of disease caused by HHVs and HPV infections and cancers caused by the oncoviruses Epstein-Barr Virus, HHV-8 and HPV. This workshop examined four questions regarding the viruses associated with oral cancers and disease in the HIV-positive and -negative populations, the immune response, and biomarkers useful for accurate diagnostics of these infections and their sequalae. Each presenter identified a number of key areas where further research is required.