Protective effect of Hua Tan Qu Shi decoction against liver injury in rats with nonalcoholic fatty liver disease

Protective effect of Hua Tan Qu Shi decoction against liver injury in rats with nonalcoholic fatty liver disease
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化痰祛湿汤对非酒精性脂肪肝大鼠肝损伤的保护作用

DOI:
10.1016/j.biopha.2017.04.099
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发表时间:
2017
影响因子:
7.5
通讯作者:
Wang Qi
Wang Qi
中科院分区:
医学2区
文献类型:
--
作者:
Zhao Shi Peng;Wu Zhi Sheng;Chen Yu;Liang Xue;Bao Lei;Li Pin;Sun Ran Ran;Wu Yan Ling;Li Ling Ru;Wang Qi

文献摘要

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BackgroundNonalcoholic fatty liver disease (NAFLD), is currently a worldwide health problem. None of the existing treatment medications had got a satisfactory effect. Hua Tan Qu Shi (HTQS) decoction is a Chinese herbal formula, which has been used clinically to treat NAFLD for years. However, the underlying mechanisms are still unclear.MethodsHigh-fat diet (HFD) induced non-alcoholic fatty liver disease rats treated with or without HTQS decoction by gavage for 10 weeks and examined by serology, 24-h albuminuria, histology, immunohistochemistry, and molecular analyses.