Dose-response studies for the elicitation of CD8 T cells by a DNA vaccine, used alone or as the prime for a modified vaccinia Ankara boost
Dose-response studies for the elicitation of CD8 T cells by a DNA vaccine, used alone or as the prime for a modified vaccinia Ankara boost
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DOI：
10.1016/j.vaccine.2006.05.081
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发表时间：
2007-04-12
期刊：
影响因子：
5.5
通讯作者：
Robinson, Harriet L.
中科院分区：
文献类型：
--
作者：
Liu, Jinyan;Hellerstein, Michael;Robinson, Harriet L.
在这里，我们在小鼠中进行剂量反应研究，以通过表达HIV Gag的DNA疫苗诱导CD 8 T细胞。对于1至100 μ g范围内的DNA剂量，研究显示，在DNA初免或DNA初免和恒定的修饰的安卡拉牛痘（MVA）加强后，抗Gag CD 8 T细胞增加超过10倍。这些结果与表达Gag的MVA载体的剂量-反应研究相反，其中剂量增加100倍仅引起抗Gag CD 8 T细胞增加2-3倍。(c)2006爱思唯尔有限公司保留所有权利。
Here, we conduct dose-response studies in mice for the elicitation of CD8 T cells by a DNA vaccine that expresses HIV Gag. For DNA doses ranging from 1 to 100 mu g, the studies revealed greater than 10-fold increases in anti-Gag CD8 T cells following a DNA prime or a DNA prime and a constant modified vaccinia Ankara (MVA) boost. These results are in contrast to dose-response studies for MVA vectors expressing Gag, where only 2-3-fold increases in anti-Gag CD8 T cells were elicited by 100-fold increases in dose. (c) 2006 Elsevier Ltd. All rights reserved.