New C band markers of human chromosomes: C band position variants.
New C band markers of human chromosomes: C band position variants.
复制标题
人类染色体的新 C 带标记：C 带位置变异。
DOI：
10.1136/jmg.17.5.380
复制
发表时间：
1980
影响因子：
4
通讯作者：
Phillips,RB
中科院分区：
文献类型：
--
作者：
Phillips,RB
虽然众所周知，人类染色体的中心异染色质的大小变化是常见的，但尚未认识到中心异染色质可能完全位于短臂上，中心异染色质可能完全位于长臂上。对先前用Q带鉴定的染色体进行的C带核型检查显示，A、B、C、E和f组的所有染色体都有C带位置变异。这些“新的”C带标记在家族中被跟踪，并发现是可遗传的。通过对染色体C带的大小和位置进行评分，应该可以区分大多数人的大多数同源染色体。易于评分和高频率的变异应该使C带位置变异在连锁研究和人口调查中非常有用。
Although it is well known that variations in size are common in the centric heterochromatin of human chromosomes, it has not been appreciated that centric heterochromatin may be positioned either entirely on the short arm, centrally, or entirely on the long arm. Inspection of C banded karyotypes in which chromosomes were identified by previous Q banding showed C band position variants in all of the chromosomes of groups A, B, C, E, and F. These 'new' C band markers were followed in families and found to be heritable. By scoring chromosomes for both size and position of C bands it should be possible to distinguish the majority of homologous chromosomes in most people. The ease of scoring and high frequency of variation should make C band position variants extremely useful in linkage studies and population surveys.