Uveal Melanoma: Trends in Incidence, Treatment, and Survival
Uveal Melanoma: Trends in Incidence, Treatment, and Survival
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DOI：
10.1016/j.ophtha.2011.01.040
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发表时间：
2011-09-01
期刊：
影响因子：
13.7
通讯作者：
Topham, Allan K.
中科院分区：
文献类型：
--
作者：
Singh, Arun D.;Turell, Mary E.;Topham, Allan K.
目的：确定 1973 年至 2008 年 36 年间美国原发性葡萄膜黑色素瘤的发病率、治疗和生存趋势。设计：对现有数据库进行系统回顾。参与者：总共 4070 名原发性葡萄膜黑色素瘤患者（国际肿瘤学疾病分类 [ICD-O-2] 代码 C69.3 [脉络膜]、C69.4 [睫状体和虹膜]和C69.2 [视网膜]）源自1973年至2008年美国的监测、流行病学和最终结果（SEER）计划数据库。方法：使用卡方检验和95％置信区间（CI）确定年龄调整发病率、治疗和5年相对生存率趋势的显着性。主要结果指标：年龄调整发病率、治疗形式（手术、放射或两者）和 5 年相对生存率。结果：共有 4070 例葡萄膜黑色素瘤病例，占所有记录的黑色素瘤病例的 3.1%。大多数病例（98.3%）是由医院住院/门诊诊所报告的。 2804 例病例获得了组织病理学证实（历年为 72.1%）。在美国，葡萄膜黑色素瘤的平均年龄调整发病率为百万分之 5.1（95% CI，4.8 -5.3）。大多数病例（97.8%）发生在白人中。性别之间年龄调整后的发病率存在统计学显着差异（男性 = 5.8，95% CI，5.5-6.2；女性 = 4.4，95% CI，4.2-4.7）。仅接受手术治疗的患者出现下降趋势（1973-1975 年为 93.8%，2006-2008 年为 28.3%），而接受放射治疗的患者则相应增加（1973-1975 年为 1.8%，2006-2008 年为 62.5%）。从 1973 年到 2008 年，观察到 5 年相对生存率 (81.6%) 没有变化。结论：从 1973 年到 2008 年，葡萄膜黑色素瘤的年龄调整发病率（百万分之 5.1）保持不变。尽管转向更保守的治疗，但在此期间生存率并未改善。财务披露：作者对本文中讨论的任何材料没有专有或商业利益文章。眼科学2011; 118：1881-1885 (C) 2011 年，美国眼科学会。
Purpose: To determine trends in incidence, treatment, and survival with primary uveal melanoma in the United States over a 36-year period from 1973 to 2008.Design: Systematic review of existing databases.Participants: A total of 4070 patients with primary uveal melanoma (International Classification of Disease for Oncology [ICD-O-2] codes C69.3 [choroid], C69.4 [ciliary body and iris], and C69.2 [retina]) derived from the Surveillance, Epidemiology, and End Results (SEER) program database in the United States from 1973 to 2008.Methods: The significance of trends in age-adjusted incidence, treatment, and 5-year relative survival rates were determined using chi-square testing and 95% confidence intervals (CIs).Main Outcome Measures: Age-adjusted incidence, form of treatment (surgery, radiation, or both), and 5-year relative survival rates.Results: There were 4070 cases of uveal melanoma representing 3.1% of all recorded cases of melanoma. The majority of cases (98.3%) were reported by hospital inpatient/outpatient clinics. Histopathologic confirmation was available in 2804 cases (72.1% for all years). The mean age-adjusted incidence of uveal melanoma in the United States was 5.1 per million (95% CI, 4.8 -5.3). The majority of cases (97.8%) occurred in the white population. There was a statistically significant variation of age-adjusted incidence between sexes (male = 5.8, 95% CI, 5.5-6.2; and female = 4.4, 95% CI, 4.2-4.7). A decreasing trend was observed in patients treated with surgery alone (93.8% for 1973-1975 vs. 28.3% for 2006-2008), whereas a corresponding increase was seen in those treated with radiation (1.8% for 1973-1975 vs. 62.5% for 2006-2008). No change in the 5-year relative survival rate (81.6%) was observed from 1973 to 2008.Conclusions: The age-adjusted incidence of uveal melanoma (5.1 per million) has remained unchanged from 1973 to 2008. Despite a shift toward more conservative treatments, survival has not improved during this time period.Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. Ophthalmology 2011; 118: 1881-1885 (C) 2011 by the American Academy of Ophthalmology.