Feasibility/Flexibility-based optimization for process design and operations
Feasibility/Flexibility-based optimization for process design and operations
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DOI：
10.1016/j.compchemeng.2023.108461
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发表时间：
2023-10
期刊：
影响因子：
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通讯作者：
Huayu Tian;Jnana Sai Jagana;Qi Zhang;M. Ierapetritou
中科院分区：
文献类型：
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作者：
Huayu Tian;Jnana Sai Jagana;Qi Zhang;M. Ierapetritou
本文提供了一个概述的概念和计算方法的可行性/灵活性的评估，以及如何将它们用于工艺设计和工艺操作优化。它强调在这一领域，特别是可行区域评估，可行性为基础的优化，优化与灵活性的要求最近的主题。过程可行性的描述和基于可行性的优化问题，提出了一种有效地将多个约束，并避免不必要的探索在黑箱优化上下文中的不可行空间的方式。灵活性分析和强大的优化之间的关系也突出了，并在探索其中的协同作用的机会进行了概述。在制药设计和工艺调度中的应用被用来提供所提出的方法的利用背景。
This paper provides an overview of concepts and computational approaches for the evaluation of feasibility/flexibility and how they can be used for process design and process operations optimization. It emphasizes more recent topics in this area, in particular feasible region evaluation, feasibility-based optimization, and optimization with flexibility requirements. The description of process feasibility and the feasibility-based optimization problem are presented as a way to efficiently incorporate multiple constraints and avoid unnecessary exploration of the infeasible space in the black-box optimization context. The relationship between flexibility analysis and robust optimization is also highlighted, and opportunities in exploring synergies therein are outlined. Applications in pharmaceutical design and process scheduling are used to provide context in the utilization of the presented approaches.