Neural oscillations in the primate caudate nucleus correlate with different preparatory states for temporal production
Neural oscillations in the primate caudate nucleus correlate with different preparatory states for temporal production
复制标题
灵长类尾状核中的神经振荡与时间产生的不同准备状态相关
DOI：
10.1038/s42003-019-0345-2
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发表时间：
2019
影响因子：
5.9
通讯作者：
Tanaka Masaki
中科院分区：
文献类型：
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作者：
Suzuki Tomoki W.;Tanaka Masaki
在测量时间时，皮质-基底神经节通路中的神经元活动已被证明是根据间隔时间而在时间上缩放的，这表明通路内的信号传递是灵活控制的。在实验中，我们发现，在三种不同的时间间隔中，猴子尾状核的视觉诱发电位的大小在不同的时间间隔开始时不同。在此响应之前，低频分量（6-20 Hz）的功率发生了显著变化，与视觉响应增益呈负相关。尽管这些成分后来在自定时期间表现出时间依赖性的变化，但间隔条件下谱功率的变化在定性和定量上都不同于与奖励量相关的谱功率变化。这些结果表明，低频振荡指示的皮质-基底神经节通路网络状态的改变可能对信号传递和随后的时序行为的调节至关重要。
When measuring time, neuronal activity in the cortico-basal ganglia pathways has been shown to be temporally scaled according to the interval, suggesting that signal transmission within the pathways is flexibly controlled. Here we show that, in the caudate nuclei of monkeys performing a time production task with three different intervals, the magnitude of visually-evoked potentials at the beginning of an interval differed depending on the conditions. Prior to this response, the power of low frequency components (6–20 Hz) significantly changed, showing inverse correlation with the visual response gain. Although these components later exhibited time-dependent modification during self-timed period, the changes in spectral power for interval conditions qualitatively and quantitatively differed from those associated with the reward amount. These results suggest that alteration of network state in the cortico-basal ganglia pathways indexed by the low frequency oscillations may be crucial for the regulation of signal transmission and subsequent timing behavior.