Relationship between LAPTM4B gene polymorphism and susceptibility of primary liver cancer
Relationship between LAPTM4B gene polymorphism and susceptibility of primary liver cancer
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LAPTM4B基因多态性与原发性肝癌易感性的关系
DOI：
10.1093/annonc/mdr538
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发表时间：
2012-07-01
影响因子：
50.5
通讯作者：
Zhou, R-L
中科院分区：
文献类型：
--
作者：
Wang, S.;Zhang, Q-Y;Zhou, R-L
溶酶体相关跨膜蛋白4 β（LAPTM 4 B）是首次发现的在人肝细胞癌中高表达的新基因。LAPTM 4 B *1和LAPTM 4 B *2是该基因的两个等位基因;它们在第一外显子的5 'UTR处区分。等位基因 *1在5 'UTR中仅含有一个拷贝的19-bp序列。然而，等位基因 *2包含另一个相同的19 bp序列，紧接着第一个。为探讨LAPTM 4 B基因多态性与原发性肝癌易感性的关系，本研究在中国进行了病例对照研究，包括303例原发性肝癌患者和515例对照。PCR检测LAPTM 4 B基因多态性。采用非条件Logistic回归分析方法计算比值比（OR）和95%可信区间（CI），结果发现LAPTM 4 B *2在病例组和对照组中的分布差异有统计学意义（P < 0.05）。我们的研究表明，与LAPTM 4 B *1/1相比，LAPTM 4 B *1/2和 *2/2与原发性肝癌的风险显著增加（OR分别为1.898，95% CI = 1.387-2.598和OR = 2.483，95% CI = 1.480-4.168）。LAPTM 4 B基因型与临床病理结果呈负相关，提示LAPTM 4 B基因多态性可能影响个体原发性肝癌的易感性，等位基因 *2可能是一个潜在的危险因素。
Lysosome associated protein transmembrane 4 beta (LAPTM4B) was identified first as a novel gene overexpressed in human hepatocellular carcinoma. LAPTM4B*1 and LAPTM4B*2 are two alleles of the gene; they are differentiated at 5'UTR in the first exon. Allele *1 contains only one copy of a 19-bp sequence in the 5'UTR. However, allele *2 contains another identical 19-bp sequence following the first one tightly. In this case-control study, we aimed to identify the relationship between LAPTM4B gene polymorphism and the susceptibility of primary liver cancer.The case-control study was conducted in China, including 303 primary liver cancer cases and 515 controls. LAPTM4B gene polymorphism was determined by PCR. Statistical analysis includes odds ratio (OR) and 95% confidence interval (CI) calculations using unconditional logistic regression.We found a significant difference in the frequency of LAPTM4B*2 between cases and controls (P < 0.05). Our study showed that LAPTM4B*1/2 and *2/2 were associated with a significantly increased risk of primary liver cancer compared with LAPTM4B*1/1 (OR = 1.898, 95% CI = 1.387-2.598 and OR = 2.483, 95% CI = 1.480-4.168, respectively). The genotypes of LAPTM4B in this study have negative correlation with the clinicopathologicals observed.The evidences suggest that gene polymorphism of LAPTM4B may influence the individuals' susceptibility to primary liver cancer and allele *2 being considered as a potential risk factor.