Inhibition of progenitor cell proliferation in the dentate gyrus of rats following post-weaning lead exposure
Inhibition of progenitor cell proliferation in the dentate gyrus of rats following post-weaning lead exposure
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DOI：
10.1016/j.neuro.2004.06.006
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发表时间：
2005-01-01
期刊：
影响因子：
3.4
通讯作者：
Lidsky, TI
中科院分区：
文献类型：
--
作者：
Schneider, JS;Anderson, DW;Lidsky, TI
虽然铅是一种有效的发育神经毒素，但出生后铅暴露对海马中祖细胞增殖的影响尚未得到研究。出生后第25天的大鼠喂食含铅饮食（1500 ppm乙酸铅）30-35天，并在第25天给予溴脱氧尿苷（BrdU，50 mg/kg，i. p.）在铅暴露的最后5天内。最后一次注射BrdU后24 h处死动物。在颗粒下区和齿状回的新细胞的增殖显着减少铅暴露的大鼠相比，吃了类似的饮食没有铅的对照动物。这些结果表明，出生后铅暴露可以有显着的有害影响祖细胞增殖，从而海马的结构和功能。(C)2004年爱思唯尔公司All rights reserved.
Although lead is a potent developmental neurotoxin, the effects of postnatal lead exposure on progenitor cell proliferation in the hippocampus has not been examined. Postnatal day 25 rats were fed a lead containing diet (1500 ppm lead acetate) for 30-35 days and administered bromodeoxyuridine (BrdU, 50 mg/kg, i.p.) during the last 5 days of lead exposure. Animals were killed 24 h after the last BrdU injection. Proliferation of new cells in the subgranular zone and dentate gyrus was significantly decreased in lead-exposed rats compared to control animals that ate a similar diet devoid of lead. These results suggest that postnatal lead exposure can have significant deleterious effects on progenitor cell proliferation and thus the structure and function of the hippocampus. (C) 2004 Elsevier Inc. All rights reserved.