Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women
Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women
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DOI：
10.1038/ncomms5682
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发表时间：
2014-08-01
影响因子：
16.6
通讯作者：
Wei, Qingyi
中科院分区：
文献类型：
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作者：
Chen, Kexin;Ma, Hongxia;Wei, Qingyi
卵巢癌是世界范围内妇科恶性肿瘤死亡的主要原因。在这里，我们在中国汉族妇女中进行了一项三阶段的全基因组关联研究，以确定上皮性卵巢癌(EOC)的风险基因变异。我们在第一阶段扫描了1057例卵巢癌患者和1191例对照的900,015个单核苷酸多态(SNPs)，并复制了41个SNPs(P-Meta
Ovarian cancer is the leading cause of death from gynaecological malignancies worldwide. Here we perform a three-stage genome-wide association study (GWAS) in Han Chinese women to identify risk genetic variants for epithelial ovarian cancer (EOC). We scan 900,015 single-nucleotide polymorphisms (SNPs) in 1,057 EOC cases and 1,191 controls in stage I, and replicate 41 SNPs (P-meta