Skeletal muscle satellite cells: mediators of muscle growth during development and implications for developmental disorders.
Skeletal muscle satellite cells: mediators of muscle growth during development and implications for developmental disorders.
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DOI：
10.1002/mus.24441
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发表时间：
2014-11
期刊：
影响因子：
3.4
通讯作者：
Lieber, Richard L.
中科院分区：
文献类型：
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作者：
Dayanidhi, Sudarshan;Lieber, Richard L.
卫星细胞（SC）是负责纵向和横截面出生后生长，损伤后修复，并在需要时提供新的肌核的肌肉干细胞。在这里，我们回顾他们的形态，对发展的贡献，以及他们在肌节和肌节的作用。与其他组织干细胞类似，SC通过不同的状态循环，例如静止，激活和自我更新，因此我们考虑了维持这些状态的信号传导机制。SC生态位的作用，它们与其他细胞如成纤维细胞和细胞外基质的相互作用都是影响衰老和疾病的重要因素。有趣的是，脑瘫儿童的SC数量似乎减少，这可能在他们的肌肉发育减少甚至肌肉挛缩形成中发挥作用。最后，我们回顾了肌营养不良症儿童SC功能障碍的最新信息，以及针对促进肌生成和减少纤维化的新兴疗法。
Satellite cells (SCs) are the muscle stem cells responsible for longitudinal and cross-sectional postnatal growth, repair after injury and which provide new myonuclei when needed. Here we review their morphology, contribution to development, and their role in sarcomere and myonuclear addition. SCs, similar to other tissue stem cells, cycle through different states such as quiescence, activation, and self-renewal and thus we consider the signaling mechanisms involved in maintenance of these states. The role of the SC niche, their interactions with other cells such as fibroblasts and the extracellular matrix are all emerging as important factors that affect aging and disease. Interestingly, children with cerebral palsy appear to have a reduced SC number, which could play a role in their reduced muscular development and even in muscular contracture formation. Finally we review the current information on SC dysfunction in children with muscular dystrophy and emerging therapies that target promotion of myogenesis and reduction of fibrosis.
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影响因子：
2.8
作者：
Decary, S;Ben Hamida, C;Butler-Browne, GS
通讯作者：
Butler-Browne, GS
影响因子：
64.8
作者：
Conboy, IM;Conboy, MJ;Rando, TA
通讯作者：
Rando, TA
影响因子：
11.8
作者：
Conboy, IM;Rando, TA
通讯作者：
Rando, TA
DOI：
10.1083/jcb.200405004
发表时间：
2004-09-13
期刊：
The Journal of cell biology
影响因子：
--
作者：
Engler AJ;Griffin MA;Sen S;Bönnemann CG;Sweeney HL;Discher DE
通讯作者：
Discher DE
DOI：
10.1038/nrm3591
发表时间：
2013-06
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
通讯作者：
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