Unexpected high rate of de novo constitutional t(11;22) translocations in sperm from normal males
Unexpected high rate of de novo constitutional t(11;22) translocations in sperm from normal males
复制标题
DOI：
10.1038/ng1001-139
复制
发表时间：
2001-10-01
期刊：
影响因子：
30.8
通讯作者：
Emanuel, BS
中科院分区：
文献类型：
--
作者：
Kurahashi, H;Emanuel, BS
先前已克隆和测序了来自组成性t（11;22）（q23;q11）易位的连接片段。在这里，我们报告了一个高发病率的易位特异性PCR产物在精子DNA从正常人。来自这些和其他正常个体或来自染色体断裂综合征患者的体细胞DNA不产生PCR连接片段，表明这种易位起源于减数分裂期间。
Junction fragments from the constitutional t(11;22)(q23;q11) translocation have previously been cloned and sequenced. Here we report a high incidence of translocation-specific PCR products in sperm DNA from normal individuals. Somatic DNA from these and other normal individuals or from people with chromosomal breakage syndromes do not yield PCR junction fragments, indicating that this translocation originates during meiosis.